Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Explores the use of nanotechnology for medical applications with focus on its use for drug delivery, especially in cancer research

Loutfy H. Madkour (Author)

9780128197776, Elsevier Science

Paperback, published 15 August 2019

650 pages, 123 illustrations (91 in full color)
22.9 x 15.1 x 4 cm, 1.04 kg

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

1. Advanced drug delivery systems: New nanomedication technologies2. Characteristics of deoxyribonucleic acid3. Characteristics of ribonucleic acid4. Clinical applications of nucleic acid (DNA) gene therapeutics delivery systems5. Therapeutic applications of siRNA gene delivery systems6. Targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy7. Classifications of DNA binding molecules - Drug interactions8. Structures of quadruplex nucleic acids and their drug complexes9. Solvent-accessible surfaces of proteins and nucleic acids10. Nucleic acid medicines as green novel anticancer drugs11. Correlation between nucleic acids and nanoparticle therapeutics for cancer treatment12. Drug delivery systems as advanced nanotechnology13. Nanoparticle and polymeric nanoparticle-based targeted drug delivery systems14. Polymer nanoparticle drug-nucleic acid combinations15. Combinational delivery therapies of nucleic acids for cancer treatment16. Multiple delivery of drug-nucleic acid combinations for cancer treatment17. FDA and the medical device clinical drug trials18. Biological barriers to cancer drug delivery, efficacy and cancer models19. Toxicological considerations of clinically applicable nanoparticles20. DNA complexes as an efficient gene anticancer drug delivery therapy21. Immunotherapy with mRNA vaccination and immunomodulation nanomedicine for cancer therapy

Subject Areas: Materials science [TGM], Biotechnology [TCB], Genetics [non-medical PSAK], Biomedical engineering [MQW], Pharmacology [MMG], Cytology [MFCC], Pharmaceutical industries [KNDP]