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Nonsense Mutation Correction in Human Diseases
An Approach for Targeted Medicine
This introduction to genetic diseases discusses the impact of nonsense mutations on gene expression and mRNA decay, and includes information on the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD)
Fabrice Lejeune (Author), Hana Benhabiles (Author), Jieshuang Jia (Author)
9780128044681
Paperback / softback, published 21 April 2016
190 pages
22.9 x 15.1 x 1.3 cm, 0.32 kg
"Not only is the content well selected and planned, but the language is clear and simple and the illustrations are magnificent…This book is unique - there are no comparable books. The authors have achieved a tremendous goal. Score: 100 - 5 Stars!" --Doody's
Nonsense Mutation Correction in Human Diseases: An Approach for Targeted Medicine provides an introduction on genetic diseases, discusses the prevalence of nonsense mutations, the consequences of a nonsense mutation for the expression of the mutant gene, and the presentation of the nonsense-mediated mRNA decay (NMD). It presents the mechanism of action and rationale associated with each strategy to correct nonsense mutations with the results of clinical trials to further support this basis. In addition, the book shows how it may be possible to combine several of these strategies to ultimately improve the efficiency of correction, also suggesting the future goals and objectives to improve treatment modalities in this evolving sphere of personalized medicine.
1. General aspects related to nonsense mutations2. Pathologies susceptible to be targeted for nonsense mutation therapies3. Strategies to correct nonsense mutations4. Conclusions
Subject Areas: Genetics [non-medical PSAK]
