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NMR in Pharmaceutical Science
Jeremy R. Everett (Edited by), Robin K. Harris (Edited by), John C. Lindon (Edited by), Ian D. Wilson (Edited by)
9781118660256, Wiley
Hardback, published 18 September 2015
512 pages
25.4 x 19.6 x 2.8 cm, 1.247 kg
NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips!
Visit: www.wileyonlinelibrary.com/ref/eMagRes
Contributors xi Series Preface xvii Preface xix Part A: Introduction 1 1 Drug Discovery and Development: The Role of NMR Part B: NMR Theory & Experimental Methods 21 2 Modern NMR Pulse Sequences in Pharmaceutical R&D 3 Experimental NMR Methods for Pharmaceutical Research and Development 4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies 5 Quantitative NMR Spectroscopy in Pharmaceutical R&D 6 High-throughput NMR in Pharmaceutical R&D 7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research Part C: Idea to Lead 103 8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D 9 High-resolution MAS NMR of Tissues and Cells 10 NMR Studies of Inborn Errors of Metabolism 11 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R&D 12 Fragment-based Drug Design Using NMR Methods 13 Hit Discovery from Natural Products in Pharmaceutical R&D Part D: Lead to Drug Candidate 183 14 NMR-based Structure Determination of Drug Leads and Candidates 15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR Techniques 16 Conformation and Stereochemical Analysis of Drug Molecules 17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds 18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety 19 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism Studies 20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy 21 Characterization of Pharmaceutical Compounds by Solid-state NMR 22 Structure-based Drug Design Using NMR 23 Pharmaceutical Technology Studied by MRI Part E: Clinical Development 345 24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification 25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine 26 Clinical MRI Studies of Drug Efficacy and Safety 27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&D Part F: Drug Manufacture 395 28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR 29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy 30 NMR Spectroscopy in the European and US Pharmacopeias 31 NMR in Pharmaceutical Manufacturing Index 453
Jeremy R. Everett 3
John A. Parkinson 23
Anthony C. Dona 41
John C. Lindon and Ian D. Wilson 53
Ulrike Holzgrabe 63
John C. Hollerton 79
Kirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89
Krishna Saxena and Harald Schwalbe 105
Leo L. Cheng 117
Sarantos Kostidis and Emmanuel Mikros 131
Philip J. Sidebottom 147
Leonor Puchades-Carrasco and Antonio Pineda-Lucena 155
Olivia Corcoran 173
Torren M. Peakman 185
Ian D. Wilson and John C. Lindon 197
Gary J. Sharman 207
Jose M. Seco and Ricardo Riguera 221
Thomas M. Bocan, Lauren Keith, and David M. Thomasson 255
Raman Sharma and Gregory S. Walker 267
Muireann Coen and Ian D. Wilson 281
Frederick G. Vogt 297
Mark Jeeves, Lee Quill, and Michael Overduin 317
David G. Reid and Stephen J. Byard 331
Beatriz Jiménez 347
Jeremy R. Everett 359
David G. Reid, Paul D. Hockings, and Nadeem Saeed 373
Frederick G. Vogt 385
Myriam Malet-Martino and Robert Martino 397
Andrea Ruggiero and Sarah K. Branch 413
Helen Corns and Sarah K. Branch 425
Edwin Kellenbach and Paulo Dani 441
Subject Areas: Chemistry [PN]
