Neurotropic Viral Infections

A depiction of viruses that infect the brain, their treatment, and novel beneficial uses of them.

Carol Shoshkes Reiss (Edited by)

9780521869645, Cambridge University Press

Hardback, published 16 October 2008

484 pages, 64 b/w illus. 12 colour illus. 28 tables
25.7 x 19.4 x 2.7 cm, 1.2 kg

'… comprehensive, well illustrated and very readable. … I highly recommend it to all those interested in viruses and neurological disease.' Microbiology Today

Viral infections of the central nervous system or neurotropic viruses are often lethal. These diseases range from polio and measles, to rabies, Varicella-zoster, Herpes, West Nile, Japanese encephalitis, and AIDS. Such infections have profound public health consequences, and the understanding of these diseases involves understanding the interaction between the nervous system and the immune system. This book shows each individual virus, discussing the diseases they cause and the mechanisms by which they cause and spread those diseases. Detection, treatment and prevention are also discussed. Included is coverage of novel and beneficial uses of neurotropic viruses for gene therapy and tumor lysis. Neurotropic Viral Infection has been written in a style suitable for a wide professional audience, and will appeal to anyone from graduate students and postdocs to clinicians and public health professionals.

Preface. Howard Lipton
Forward and acknowledgments Carol Shoshkes Reiss
Part I. RNA Viruses: Introduction Carol Shoshkes Reiss
1. Neurotropic picornaviruses Vincent Racaniello
2. Subacute sclerosing panencephalitis James Bale and Robert S. Fujinami
3. Rabies Monique Lafon
4. Neurotropic coronavirus infections Stanley Perlman and Noah Butler
5. Arenavirus infection in the nervous system: uncovering principles of virus-host interaction and viral pathogenesis Stefan Kunz and Juan-Carlos de la Torre
6. Neurotropic alphaviruses Diane E. Griffin
7. Flaviviruses Barbara W. Johnson
Part II. Retroviruses, DNA Viruses and Prions: Introduction Carol Shoshkes Reiss
8. HTLV-1 and disease in the central nervous system Angelina J. Mosley and Charles R. M. Bangham
9. HIV infection of the central nervous system Iain C. Anthony P Simmonds and J. E. Bell
10. JC virus molecular biology and the human demyelinating disease, progressive multifocal leukoencephalopathy Kamel Khalili, Mahmut Safak, Luis Del Valle and Martyn K. White
11. Herpes simplex viruses David C. Bloom and Nicole V. Giordani
12. Pathogenesis of varicella-zoster virus neurotropism and infection Leigh Zerboni and Ann M. Arvin
13. Transmissible spongiform encephalopathies Surachai Supattapone and Judy R. Rees
Part III. Immunity, Diagnosis, Vectors and Beneficial Uses of Neurotropic Viruses: Introduction Carol Shoshkes Reiss
14. Innate immunity in the CNS Carol Shoshkes Reiss
15. The role of toll like receptors in neurotropic viral infections Robert W. Finberg, Shenghua Zhou and Evelyn A. Kurt-Jones
16. Neuro-endocrine-immune networks in viral infections C. Jane Welsh, Andrew J. Steelman, Amy N. Sieve, Wentao Mi, Robin R. Johnson, Colin R. Young, Thomas W. Prentice and Mary W. Meagher
17. Epidemiology of viral encephalitis Nino Khetsuriani and Larry J. Anderson
18. Pathogen surveillance and discovery W. Ian Lipkin and Thomas Briese
19. Clinical management of viral encephalitis Kenneth L. Tyler and Don Gilden
20. Influences of arthropod vectors on encephalitic arboviruses Stephen T. Higgs
21. The role of bats as reservoir hosts of emerging neurological viruses John S. Mackenzie, James E. Childs, Hume E. Field, Lin-Fa Wang and Andrew C. Breed
22. Viral oncolysis of glioblastoma William T. Curry, Jr. and Robert L. Martuza
23. Viral gene therapy for central nervous system disorders Pedro R. Lowenstein, Kurt M. Kroeger and Maria G. Castro.

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN], Immunology [MJCM]