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Neuropsychiatric Disorders and Epigenetics
This volume defines the epigenetic mechanisms underlying neuropsychiatric disorders and introduces potentially revolutionary epigenetic therapies for each condition
Jacob Peedicayil (Edited by), Dennis R. Grayson (Edited by)
9780128002261
Hardback, published 6 December 2016
444 pages, 80
23.4 x 19 x 2.8 cm, 1.06 kg
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Preface Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson Section I. Neuropsychiatric Disorders and Epigenetics: General Aspects 1. Introduction to Neuropsychiatric Disorders and Epigenetics Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson 2. Environmental Factors and Epigenetics of Neuropsychiatric Disorders Anke Hoffmann and Dietmar Spengler 3. Epigenetic Biomarkers in Neuropsychiatric Disorders Chin-Chuen Lin, Tiao-Lai Huang Section II: Epigenetics of Neuropsychiatric Disorders 4. Epigenetics and Cognitive Disorders -Translational Aspects Fabio Coppedè 5. Epigenetics in Pervasive Developmental Disorders - Translational Aspects Takeo Kubota 6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigm Elisabetta Tabolacci, Giovanni Neri 7. Epigenetics of Attention-Deficit Hyperactivity Disorder Nader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer 8. The epigenetics of brain aging and psychiatric disorders Huan Gong, Xiangru Xu 9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene products Alain D. Dekker, Peter P. De Deyn and Marianne G. Rots 10. Epigenetics and Multiple Sclerosis Lara Kular, Gonçalo Castelo-Branco and Maja Jagodic 11. Epigenetics and Migraine Siew Hua Gan and Munvar Miya Shaik 12. The role of epigenetics in the pathophysiology of epilepsy Sung Min Nam and Kyung-Ok Cho 13. Epigenetic Dysregulation in Brain Tumors and Neurodevelopment Marco M. Hefti and Nadejda Tsankova 14. Epigenetics and Cerebrovascular Diseases Carolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer 15. Epigenetics and Eating Disorders Helge Frieling, Vanessa Buchholz 16. Epigenetics in Obesity Brian M. Shewchuk 17. Epigenetics and Drug Addiction-Translational Aspects Jian Feng 18. Epigenetics and Alcohol Use Disorders Sneha Sagarkar and Amul Sakharkar Section III: Summary and Outlook 19. Summary and Outlook Dag H. Yasui, Jacob Peedicayil and Dennis R. Grayson
Subject Areas: Medical genetics [MFN], Physiological & neuro-psychology, biopsychology [JMM]
