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Neurodegeneration

Anthony Schapira (Edited by), A Schapira (Author), Zbigniew K. Wszolek (Edited by), Ted M. Dawson (Edited by), Nicholas Wood (Edited by)

9780470672686, Wiley

Hardback, published 21 April 2017

344 pages
28.4 x 22.6 x 3.3 cm, 1.179 kg

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject.

  • Presents a clinically oriented guide to the diseases caused by neurodegeneration 
  • Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually
  • Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases 
  • Edited by globally leading authorities on the subject, and written by expert contributing authors

List of Contributors, vi

Preface, ix

Dedication, x

1 Pathology of Brain Aging, 1
Janna H. Neltner and Peter T. Nelson

2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12
Michel Goedert

3 Prion Degeneration, 25
James A. Mastrianni

4 Excitotoxicity, 37
Mark P. Mattson

5 Etiology and Pathogenesis of Parkinson Disease, 46
Ruth-Mary deSouza and Anthony H.V. Schapira

6 Parkinson Disease: Treatment Options – Surgical Therapy, 53
Travis S. Tierney and Andres M. Lozano

7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58
Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross

8 Progressive Supranuclear Palsy, 72
Huw R. Morris

9 Dementia with Lewy Bodies, 83
Rodolfo Savica and David S. Knopman

10 Corticobasal Degeneration, 93
Keith A. Josephs, Jr.

11 Alzheimer’s Disease, 102
Qurat ul Ain Khan and Neill R. Graff-Radford

12 Frontotemporal Dementia, 115
Christian W. Wider, Barbara Jasinska-Myga, Takuya Konno, and Zbigniew K. Wszolek

13 Prion Diseases and Other Rapidly Progressive Dementias, 126
Eric Eggenberger and Daniel L. Murman

14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137
Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson

15 Hereditary Spastic Paraplegia, 161
Pawel P. Liberski and Craig Blackstone

16 Spinal Muscular Atrophy, 179
Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner

17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202
Erich Peter Bosch

18 Optic Neuropathies, 211
Desmond Kidd

19 Peripheral Nerve Neuropathies Including Charcot–Marie–Tooth Disease, 218
Amelie Pandraud and Henry Houlden

20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238
Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp

21 Huntington’s Disease and Other Choreas, 248
Salman Haider, Edward Wild, and Sarah J. Tabrizi

22 Spinocerebellar Ataxias, 284
H. Brent Clark and Harry T. Orr

23 Ataxia Telangiectasia, 296
Malcolm Taylor

24 Niemann–Pick Disease, 303
Marc C. Patterson

25 X-linked Adrenoleukodystrophy, 309
Deborah L. Renaud

26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317
Alisdair McNeill

Index, 327

Subject Areas: Clinical & internal medicine [MJ]
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