I. Setting the scene and introductory chapters

1. Distribution of the endocannabinoid system: linking signalling and development Michaela Dvorakova and Anna Kalinovsky

2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation Elliot Lloyd, Nina Nguyen and Judith Hellman

3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET) Claudia Poluga, Cassis Varlow, Neil Vasdev, Isabelle Boileau and Laura M. Best

4. The endocannabinoid system and aging Prof. Vahid Reza Askari

5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative Luke Ney, Kevin M. Crombie and Leah M. Mayo

II. Neurobiology of the endocannabinoid system

6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy Rita Yakovlevna Gordon, Valentina Kitchigina and Irina Mikheeva

7. Endocannabinoid Signaling and excitatory and inhibitory synapses Jian Liang and Corette J. Wierenga

8. The endocannabinoids and potassium channels: an updated narrative Yu-Fung Lin

9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling Cheryl McCormick

10. Exercise and Parkinson's disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors Marucia Chacur Sr., Caroline Cristiano Real Gregório and Karina Henrique Binda

11. Endocannabinoids and inhalant misuse: neuropsychological aspects John Woodward

12. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders Garth E. Terry and Greta Niemela

13. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system Stevan Pecic and Ram Kandasamy

14. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease Mikiei Tanaka and Yumin Zhang

15. Endocannabinoid catabolic enzyme inhibitors and pain alleviation Sidney Stevens Negus and Clare Diester

16. The endocannabinoid system in health and disease: features in epilepsy Christopher Martínez-Aguirre, Maria de los Angeles Nuñez-Lumbreras and Luisa Lilia Rocha

17. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis Ana Bernal-Chico, Andres Baraibar, Alvaro Moreno-Garcia, Teresa Colomer, Ester Sanchez, Carmen Utrilla, Carlos Matute and Susana Mato

18. Endocannabinoid signaling and the lateral habenula Jiang-Hong Ye

19. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies Moisés Dos Santos Corrêa, Raquel Fornari, Cristina A. Stern, Leandro José Bertoglio and Lucas Gazarini

III. Receptor biology and responses

20. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation Ester Aso and Francisco Ciruela

21. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory Ana Maria Raymundi and Cristina A. Stern

22. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing Prof. S. Koyama and Thomas Heinbockel

23. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist Enzo Perez-Valenzuela and Jose Antonio Fuentealba Evans

24. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes Morvarid Kabir

25. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex Changiz Taghibiglou and Hajar Miranzadeh Mahabadi

26. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition Inês Correia-Sa

27. Role of the Transient Receptor Potential Vanilloid 1 (TRPV1), a component of the endocannabinoid system, in anxiety, depression, and cocaine addiction Carmen S. Maldonado-Vlaar and Wickensonn Norze

28. Allosteric modulators of the endocannabinoid system: Org27569 and cannabinoid receptor 1 (CB1) Dai Lu

29. Naturally occurring DELTA-9-tetrahydrocannabinol-derivatives and binding to CB1 and CB2 receptors: Linking in the endocannabinoid system Irene Reyes-Resina, Rafael Rivas-Santisteban, Iu Raïch, Claudia Llinás del Torrent, Jaume Lillo, Rafael Franco and Gemma Navarro

IV. Profiles and behaviour of selective endocannabinoids

30. New cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system Manuel Faundez-Parraguez

31. Fatty acid amide hydrolase, the endocannabinoid anandamide and neurological disease Filomena Fezza

32. The endocannabinoid-system in the immuno-biology of dendritic cells Dipyaman Ganguly

33. Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: linking in the endocannabinoid system Enza Palazzo

34. Endocannabinoid modulation of synaptic function and behavior in the dorsomedial hypothalamus Karen M. Crosby

35. Key role of anandamide and the endocannabinoid system in the modulation of cardio-renal homeostasis Prof. Virna M. Martín Gimenez and Walter Manucha

36. The endocannabinoid system: Signaling and social motivation Roberta Monterazzo Cysneiros and Fernanda Ribeiro

V. Exogenous, synthetic other compounds linking in the endocannabinoid system

37. Safety and toxicology of the dietary cannabinoid beta-caryophyllene Prof. George Oliveira Sr., Bruna Silva, Ana Santos C. L. da Silva and Luciano Silva Lopes

38. Synthetic cannabimimetics: an overview Prof. M. Kassiou

VI. Compartive studies in non neurological systems

39. Non Neurological Aspects of the Endocannabinoid System: Non Alcoholic Fatty Liver Disease Dr. R. Ghazali

40. Components of the Endocannabinoid system: Hepatic expression levels of the cannabinoid receptors and microRNAs Sema Bolkent and Zeynep Mine Coskun

41. Tumour growth and the endocannabinoid system: investigating CB2 agonists Josee Guindon, Isabel Castro-Piedras, Melissa McHann and Robert Barnes

42. Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes Susanna Molinari, Eleonora Maretti, Renata Battini and Eliana Leo

VII. Resources

43. Endocannabinoids and Resources Rajkumar Rajendram