Neural Transplantation in Neurodegenerative Disease
Current Status and New Directions

Derek J. Chadwick (Edited by), Novartis (Author), Jamie A. Goode (Edited by)

9780471492467, Wiley

Hardback, published 23 October 2000

336 pages
23.7 x 15.8 x 2.1 cm, 0.624 kg

"...well written with clear illustrations in many cases and extensively referenced..." (British Journal of Neurosurgery, Vol.16, No.6, 2002)

Ein internationales, interdisziplinäres Autorenteam diskutiert in diesem Buch Tiermodelle und klinische Anwendungen der Nerventransplantation. Angesprochen werden hochaktuelle Themen wie die Parkinsonsche Krankheit, die Hippocampus-Amnesie und der Einsatz von fetalem Gewebe zur Gewinnung von Transplantaten. Struktur und Funktionsweise von Gehirn und Rückenmark werden ausführlich erläutert. (06/00)

Introduction (J. Gray).

Cell Replacement Strategies for Neurodegenerative Disorders (A. Björklund).

Functional Analysis of Fronto-Striatal Reconstruction by Striatal Grafts (S. Dunnett).

Functional Reconstruction of the Hippocampus: Fetal Versus Conditionally Immortal Neuroepithelial Stem Cell Grafts (H. Hodges, et al.).

Gene Transfer for Neuroprotection in Animal Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis (M. Bohn, et al.).

Repair of Corticospinal Axons by Transplantation of Olfactory Ensheathing Cells (G. Raisman).

Neural Transplantation in Parkinson's Disease (O. Lindvall).

Transplantation of Human Fetal Striatal Tissue in Huntington's Disease: Rationale for Clinical Studies (T. Freeman, et al.).

GENERAL DISCUSSION I: PROSPECTS FOR FETAL TRANSPLANTS.

Neurotransplantation in Neurodegenerative Disease: A Survey of Relevant Issues in Developmental Neurobiology (J. Price, et al.).

Molecular and Cellular Mechanisms in Immune Rejection of Intracerebral Neural Transplants (T. Brevig, et al.).

Porcine Neural Xenografts: What are the Issues? (R. Barker).

Gene Transfer Techniques for the Delivery of GDNF in Parkinson's Disease (J.-L. Ridet, et al.).

Neurogenesis in the Adult Hippocampus (G. Kempermann & F. Gage).

Neural Stem Cells are Uniquely Suited for Cell Replacement and Gene Therapy in the CNS (V. Ourednik, et al.).

Functional Repair with Neural Stem Cells (J. Sinden, et al.).

Remyelinating the Demyelinated CNS (W. Blakemore, et al.).

GENERAL DISCUSSION II: THE ES CELL APPROACH.

FINAL DISCUSSION: THE FUTURE FOR FETAL GRAFTS;
STEM CELL STRATEGIES.

Index of Contributors.

Subject Index.

Subject Areas: Biology, life sciences [PS]