Networks in Cell Biology

Key introductory text for graduate students and researchers in physics, biology and biochemistry.

Mark Buchanan (Edited by), Guido Caldarelli (Edited by), Paolo De Los Rios (Edited by), Francesco Rao (Edited by), Michele Vendruscolo (Edited by)

9780521882736, Cambridge University Press

Hardback, published 13 May 2010

280 pages, 73 b/w illus.
25.5 x 18 x 1.8 cm, 0.72 kg

'This book describes the state of the art in understanding cellular networks through contributions by leaders in modern cell biology and network theory. It is clearly organized and exhibits an excellent balance between empirical studies and theory. The biological underpinnings are explained clearly and comprehensively, and the appendices give a great primer to the key mathematical concepts necessary for network analysis and modeling. This book will be of great use as a course textbook or for self-study.' Reka Albert, Pennsylvania State University

The science of complex biological networks is transforming research in areas ranging from evolutionary biology to medicine. This is the first book on the subject, providing a comprehensive introduction to complex network science and its biological applications. With contributions from key leaders in both network theory and modern cell biology, this book discusses the network science that is increasingly foundational for systems biology and the quantitative understanding of living systems. It surveys studies in the quantitative structure and dynamics of genetic regulatory networks, molecular networks underlying cellular metabolism, and other fundamental biological processes. The book balances empirical studies and theory to give a unified overview of this interdisciplinary science. It is a key introductory text for graduate students and researchers in physics, biology and biochemistry, and presents ideas and techniques from fields outside the reader's own area of specialization.

Introduction
1. Network views of the cell Paolo De Los Rios and Michele Vendruscolo
2. Transcriptional regulatory networks Sarath Chandra Janga and M. Madan Babu
3. Transcription factors and gene regulatory networks Matteo Brilli, Elissa Calistri and Pietro Lió
4. Experimental methods for protein interaction identification Peter Uetz, Björn Titz, Seesandra V. Rajagopala and Gerard Cagney
5. Modeling protein interaction networks Francesco Rao
6. Dynamics and evolution of metabolic networks Daniel Segré
7. Hierarchical modularity in biological networks: the case of metabolic networks Erzsébet Ravasz Regan
8. Signalling networks Gian Paolo Rossini
Appendix 1. Complex networks: from local to global properties D. Garlaschelli and G. Caldarelli
Appendix 2. Modelling the local structure of networks D. Garlaschelli and G. Caldarelli
Appendix 3. Higher-order topological properties S. Ahnert, T. Fink and G. Caldarelli
Appendix 4. Elementary mathematical concepts A. Gabrielli and G. Caldarelli
References.

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Genetics [non-medical PSAK], Biophysics [PHVN]