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Natural Products and Drug Discovery
An Integrated Approach
A review of the changing role of natural products in contemporary drug discovery from traditional medicinal targets, to cutting-edge molecular techniques
Subhash C. Mandal (Edited by), Vivekananda Mandal (Edited by), Tetsuya Konishi (Edited by)
9780081020814
Paperback / softback, published 23 February 2018
776 pages
22.9 x 15.1 x 4.7 cm, 1.24 kg
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers.
Section I: Traditional medicine and Drug discovery1. Drug discovery from Ayurveda: Mode of approach and applications2. Traditional and folk medicine as target for drug discovery3. Bioactivity guided phyto-fractions: an emerging natural drug discovery tool for safe and effective disease management4. Development of Chinese herbal health products for the prevention of aging-associated diseases5. Ethnobotany / ethnopharmacology and bioprospecting: Issues on knowledge and uses of medicinal plants by Moroccan people6. Chemotaxonomy of medicinal plants: Possibilities and limitations Section II: Leads from Natural Products7. The role of natural products from plants in the development of anticancer agents8. Plant drugs in the treatment of osteoporosis9. Phytodrugs and immunomodulators for the therapy of Leishmaniasis10. Natural products targeting inflammation processes and multiple mediators11. Biologically functional compounds from mushroom-forming fungi12. Natural products in lifestyle diseases: In vitro screening13. Common toxic plants and their forensic significance14. Role of stress in diseases and its remedial approach by herbal and natural products in stress related disease management: Experimental studies and clinical reports15. Anti-inflammatory medicinal plants: A remedy for most disease conditions Section III: Herbal drug research16. Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products17. Herb and drug interaction18. Toxicity studies related to medicinal plants19.Prebiotics: A functional food in health and disease20. Cultivation of medicinal plants21. Digitization of traditional knowledge22. Good agricultural practices: Requirement for the production of quality herbal medicines23. Fundamentals of microwave based sample preparation for plant based drug discovery
Subject Areas: Pharmaceutical technology [TDCW], Organic chemistry [PNN], Chemistry [PN], Pharmacology [MMG]
