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Nanotoxicity
From In Vivo and In Vitro Models to Health Risks
Saura C. Sahu (Edited by), SC Sahu (Author), Daniel A. Casciano (Edited by)
9780470741375, Wiley
Hardback, published 21 August 2009
640 pages
25.4 x 17.8 x 4.1 cm, 1.188 kg
"I can certainly envisage this book being used widely. Indeed, an excellent and most timely book, clearly written, and sensitively related to nano; above all, it really 'speaks' to the realities of nanotoxicity. An additional bonus.....an important one at that.... Is .the list of references cited at the end of every contribution that must make the acquisition of the volume urgent and imperative." (Current Engineering Practice, 2010)
Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.
Preface xi List of Contributors xiii Acknowledgments xix 1 Characterization of Nanomaterials for Toxicological Evaluation 1 2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies 29 3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines 41 4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm 61 5 Application of Zinc Oxide Quantum Dots in Food Safety 81 6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo 97 7 Evaluation of Toxicity of Nanostructures in Biological Systems 115 8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials 161 9 Nanoparticles: Is Neurotoxicity a Concern? 171 10 Hepatotoxic Potential of Nanomaterials 183 11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets 191 12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment 227 13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo 247 14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity 271 15 In Vivo and In Vitro Models for Nanotoxicology Testing 279 16 In Vitro and In Vivo Toxicity Study of Nanoparticles 303 17 In Vitro and In Vivo Models for Nanotoxicity Testing 335 18 In Vitro Models for Nanotoxicity Testing 349 19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles 379 20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms 397 21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment 427 22 Evaluating Strategies For Risk Assessment of Nanomaterials 459 23 Strategies for Risk Assessment of Nanomaterials 499 24 Metal Nanoparticle Health Risk Assessment 519 25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products 543 26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials 581 Index 597
Kevin W. Powers, Maria Palazuelos, Scott C. Brown and Stephen M. Roberts
Christie M. Sayes and David B. Warheit
Lea Ann Dailey
Craig A. Poland, Rodger Duffin and Ken Donaldson
Tony Jin, Dazhi Sun, Howard Zhang and Hung-Jue Sue
Jinsong Zhang
Adam J. Gormley and Hamidreza Ghandehari
David B. Warheit, Kenneth L. Reed and Christie M. Sayes
Jianyong Wang, Wenjun Sun and Syed F. Ali
Saura C. Sahu
Jan Simak
David S. Barber, Nancy D. Denslow, R. Joseph Griffitt and Christopher J. Martyniuk
Weiyue Feng, Bing Wang and Yuliang Zhao
Ken-ichiro Inoue and Hirohisa Takano
Rosalba Gornati, Elena Papis, Mario Di Gioacchino, Enrico Sabbioni, Isabella Dalle Donne, Aldo Milzani and Giovanni Bernardini
Jayoung Jeong, Wan-Seob Cho, Seung Hee Kim and Myung-Haing Cho
Kyung O. Yu, Laura K. Braydich-Stolle, David M. Mattie, John J. Schlager and Saber M. Hussain
Yinfa Ma
Fabian Blank, Peter Gehr and Barbara Rothen-Rutishauser
Thomas R. Pisanic, Sungho Jin and Veronica I. Shubayev
David Y. Lai and Philip G. Sayre
Nastassja Lewinski, Huiguang Zhu and Rebekah Drezek
Hae-Seong Yoon, Hyun-Kyung Kim, Dong Deuk Jang and Myung-Haing Cho
Mario Di Gioacchino, Nicola Verna, Rosalba Gornati, Enrico Sabbioni and Giovanni Bernardini
Joyce S. Tsuji, Fionna S. Mowat, Suresh Donthu and Maureen Reitman
Penelope A. Rice, Kimberly S. Cassidy, Jeremy Mihalov and T. Scott Thurmond
Subject Areas: Chemistry [PN]
