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Nano-Biosensor Technologies for Diagnosis of Infectious Diseases
Suvardhan Kanchi (Edited by), Ayyappa Bathinapatla (Edited by), Anitha Varghese (Edited by), Phumlane Selby Mdluli (Edited by)
9781394287666, Wiley
Hardback, published 13 May 2025
512 pages
28 x 19 x 3 cm, 0.666 kg
The book offers a thorough exploration of revolutionary nano-biosensor technologies that enables rapid, accurate detection of infectious diseases, critical for effective disease management in today’s world. Nano-Biosensor Technologies for Diagnosis of Infectious Diseases delves into the cutting-edge developments in nano-biosensor technology, a transformative innovation for the field of medical diagnostics. Nano-biosensors integrate nanomaterials like nanoparticles, nanowires, and nanotubes with biological recognition elements such as antibodies, nucleic acids, or enzymes to create highly sensitive and specific detection systems. These sensors exploit unique properties of nanomaterials to detect minute quantities of pathogens or biomarkers with remarkable accuracy, enabling early diagnosis and monitoring of infectious diseases. The integration of electrochemical, optical, and piezoelectric detection mechanisms further enhances the versatility and efficiency of these nano-biosensors, allowing for rapid, real-time analysis that is crucial for effective disease management. In the context of infectious diseases, nano-biosensors become particularly significant, as they can facilitate point-of-care testing (POCT), offering rapid and portable diagnostic solutions. This capability is invaluable in resource-limited settings and during outbreaks where traditional laboratory infrastructure may be lacking. The COVID-19 pandemic underscores the importance of swift and accurate diagnostic tools, spurring accelerated innovation and commercialization efforts in this domain. Nano-biosensors are now being developed and deployed to detect a wide range of pathogens with high sensitivity, providing a powerful tool in the global fight against infectious diseases. Nano-Biosensor Technologies for Diagnosis of Infectious Diseases provides a comprehensive overview of these technological advancements, exploring their applications, challenges, and future directions in the diagnosis and management of infectious diseases. Audience Biomedical engineers, material chemists, researchers, students, policymakers, and healthcare professionals interested in integrating nanomaterials in infectious disease care
Preface xv 1 Biosensor Technology: Basic Principles, Fundamentals, and History 1 1.1 Introduction 2 References 20 2 Design and Synthesis of Novel Nanomaterials Emphasizing Infectious Diseases 23 2.1 Introduction 24 2.2 Antifungal Therapy 26 2.3 Cutting-Edge Advances in Tailoring the Size, Shape, and Functionality of Nanoparticles and Nanostructures 28 2.4 Gold Silver Nanoparticle to Combat Multi-Drug Resistant Pathogen 30 2.5 Mechanism of Gold Silver Nanoparticle to Combat Multi-Drug Resistant Pathogen 31 2.6 MXenes and Borophene Nanomaterials: Highly Efficient Sensor Activity and Energy Storage Properties 34 2.7 Immunomodulatory Nanosystems 39 2.8 Lateral Flow Assays (LFAs) 40 2.9 Metal-Organic Framework (MOF) 43 2.10 Microfluidic Devices: For Detecting Disease-Specific Proteins 45 2.11 Comprehensive Overview of Nanomaterials in the Context of Cutaneous Leishmaniasis 47 2.12 Graphene Oxide (GO): A Two-Dimensional (2D) Nanomaterial 55 Conclusion 65 Future Prospect 66 Acknowledgement 67 Authors’ Contributions 68 References 68 3 Role of Nanomaterials in the Development of Nanobiosensors for Infectious Diseases 75 3.1 Introduction 76 3.2 Designing Biosensor for SARS-CoV-2 83 3.3 Conclusions and Future Perspectives 112 References 113 4 Nanobiosensors: Versatile Tool for Diagnosis of Infectious Diseases 121 4.1 Introduction 122 4.2 Nanobiosensors as Promising Devices for the Diagnosis of Coronavirus Family Members 123 4.3 Nanobiosensors for Plant Analysis 129 4.4 Three-Way Junctions Skeleton of Biosensor 135 4.5 The SpACE-CCM: Biosensor for Detection of SARS-CoV-2 Spike-ACE2 Interaction 142 4.6 Wearable Biosensor Nano and Microsystems Have Emerged as Innovative Solutions for Medical Diagnostics 146 4.7 Biosensors are Analytical Devices 153 4.8 Conclusion 159 Acknowledgement 160 Authors’ Contributions 160 References 160 5 Trends in the Development of Immunosensors for the Diagnosis of Infectious Diseases 173 5.1 Introduction 174 5.2 Immunosensors 178 5.3 Optical Immunosensor 180 5.4 Nanomaterials Immunosensor 183 5.5 Paper-Based Immunosensors 185 5.6 Viral Infectious Diseases 185 5.7 Future Perspectives and Conclusion 190 Acknowledgements 191 References 191 6 Electrochemical Nanobiosensors Approaches for Rapid Diagnosis of Infectious Diseases 197 6.1 Introduction 198 6.2 Conventional Methods for the Determination of Infectious Pathogens 199 6.3 Building Blocks of Biosensor 202 6.4 Electrochemical-Based Biosensors 206 6.5 Impact of Nanomaterials on Biosensor Performance 209 6.6 Noble Metal Nanomaterials 210 6.7 Metal Oxide Nanomaterials 214 6.8 Carbon Nanomaterials 216 6.9 Polymer Nanomaterials 218 6.10 Bionanomaterials 220 6.11 Conclusions and Future Perspectives 222 Acknowledgement 223 References 223 7 Enzymatic Nanobiosensor Strategies to Contain the Spread of Infectious Diseases 231 7.1 Introduction 232 7.2 Components of Enzymatic Biosensor 233 7.3 Enzymatic Nanobiosensors for Pathogen Detection 234 7.4 Nanozymes 235 7.5 Future Aspects 237 References 238 8 Development of Optical Nanosensors for the Detection of Infectious Diseases 241 8.1 Introduction 242 8.2 Overview of Biosensor 243 8.3 Introduction to Optical Nanosensors 246 8.4 Remarks 262 References 265 9 Aptasensors: Selective and Powerful Tools for Infectious Diseases Diagnosis 279 9.1 Introduction 280 9.2 Aptamers as Selective and Powerful Tools for Diagnostics 281 9.3 Synthesis of Aptamers 288 9.4 Application of Aptasensors in PoC Diagnostics 293 9.5 Aptasensors Impact on Infectious Disease Diagnosis 296 9.6 Drawbacks and Potential Future Work 302 9.7 Conclusions 303 References 303 10 Nanobiosensors: A Platform for the Diagnosis of Microbial Pathogens 315 10.1 Introduction 316 10.2 Microbial Pathogens 317 10.3 Diseases Caused by Pathogens 319 10.4 Importance of Pathogen Detection or Disease Diagnosis 320 10.5 Biosensors 322 10.6 Nanobiosensors as Diagnostic Platform 323 10.7 Stabilization of Biomolecules with Nanoparticles 325 10.8 Types of Nanoparticles Used in Biosensor Development 328 10.9 Challenges and Future Prospects 332 Conclusion 333 References 334 11 Micro/Nanofluidics-Integrated Biosensors for Respiratory Viral Diseases Diagnosis 341 11.1 Introduction 342 11.2 Common Respiratory Viruses and Their Detection Components 343 11.3 Biosensors 345 11.4 Fluidic Technology 347 11.5 Applications of Micro/Nanofluidic-Based Biosensors in Respiratory Virus Detection 352 11.6 Advantages of Micro/Nanofluidic Diagnosis Tools Over the Other Diagnostic Methods 356 11.7 Conclusion and Future Perspectives 356 References 357 12 Nanobiosensor System: A Robust Analytical Tool for Pandemics 365 12.1 Introduction 366 12.2 Nanobiosensors for Global Pandemics 369 12.3 Nanobiosensors for COVID-19 375 12.4 Nanobiosensors for Influenza 378 12.5 Nanobiosensors for MERS 381 12.6 Nanobiosensors for HIV/AIDS 383 12.7 Nanobiosensors for Other Human Viruses 385 12.8 Selection and Optimization of Nanomaterials for Nanobiosensors 387 12.9 Current Challenges and Prospective Solutions 391 12.10 Conclusion 392 References 393 13 Biosensing Technologies to Improve Neurological Disease Management 401 13.1 Introduction 402 13.2 Trends, Challenges, and the Disease Burden 404 13.3 CNS Diseases 404 13.4 Utility of Neurobiosensors 405 13.5 The Technology Behind Biosensor Development 406 13.6 Clinical Applications 413 13.7 Conclusion 415 References 416 14 Nanotechnology-Based Strategies for Improvement of Disease Diagnostic Systems for Future Outbreaks 423 14.1 Introduction 424 14.2 Infectious Disease Outbreaks 424 14.3 Pandemic-Potential Priority Diseases for Future Outbreaks 432 14.4 Combating Infectious Diseases Through Diagnostics 434 14.5 Nanotechnology in Diagnostics 438 14.6 Conclusion 440 References 441 15 Biocompatibility and Toxicity of Nanomaterials in the Designing of Tools for the Diagnosis of Infectious Diseases 449 15.1 Introduction 450 15.2 An Overview of Nanomaterials in Infectious Disease Diagnosis 451 15.3 Biocompatibility Assessment 453 15.4 Mechanism of Nanoparticles in the Infectious Disease Diagnosis 455 15.5 In Vitro and In Vivo Evaluation Methods of Biocompatibility Analysis 458 15.6 Toxicity of Nanomaterials 458 15.7 The Environmental and Health Hazards Caused by Nanoparticles 461 15.8 The Tools Developed for the Diagnosis of Infectious Diseases 462 15.9 Conclusion 464 References 464 16 Strengthening the Health System of the Communities in the Battle Against Infectious Diseases 469 16.1 Introduction 470 16.2 Primary Healthcare 471 16.3 Impact of COVID-19 on Infectious Diseases and Health Systems 476 16.4 Conclusion 480 References 480 Index 485
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Subject Areas: Other branches of medicine [MM]
