Multivariate Analyses of Codon Usage Biases

The distribution of the 64 codons is not uniform among coding sequences so that multivariate analyses provide an efficient way to reveal latent factors at the origin of the variability of codon usage

Jean R. Lobry (Author)

9781785482960, Elsevier Science

Hardback, published 21 November 2018

168 pages
22.9 x 15.1 x 1.8 cm, 0.4 kg

A complete case study with all coding sequences from the bacteria Borrellia burgdorferi illustrates how multivariate analyses reveals evolutionary mechanisms acting at the molecular level. They are either mutationnal (symmetric and asymmetric directionnal mutation pressure) or selective (selection against head-on collisions or linked to gene expressivity or subcellular location).

1. Introduction to correspondence analysis 2. Global codon usage 3. Synonymous codon usage 4. Non-synonymous codon usage 5. Within and between-group variability decomposition

Subject Areas: Medical bioinformatics [MBF]