Multiple Sclerosis
Recovery of Function and Neurorehabilitation

A comprehensive text on recovery of function and neurorehabilitation in multiple sclerosis, written and edited by leading experts.

Jürg Kesselring (Edited by), Giancarlo Comi (Edited by), Alan J. Thompson (Edited by)

9780521888325, Cambridge University Press

Hardback, published 7 October 2010

260 pages, 36 b/w illus. 18 colour illus. 10 tables
25.7 x 19.3 x 1.6 cm, 0.75 kg

Recent developments in basic and applied science have led to better understanding of disease mechanisms and more efficient therapies for multiple sclerosis. The most effective way of managing these patients is through a carefully planned neurorehabilitation programme. The main aims are to reduce disability and handicap and improve functions through effective training, stimulating activity and social participation. As the first text on recovery of function and neurorehabilitation in MS, this book focuses on mechanisms of recovery, application of neuroplasticity to therapeutic interventions, and determination of the efficiency of these interventions. Basic principles of neurorehabilitation in MS are described, as well as techniques for treating specific syndromes which may occur in MS. Written and edited by leading clinicians and researchers, the book achieves an excellent balance between basic science, pathophysiology, and clinical rehabilitation. An essential resource for clinicians and therapists treating patients with multiple sclerosis, neurophysiologists, and health care advisors.

Preface
Part I. Basic Mechanisms: 1. Conduction studies in multiple sclerosis Kai M. Rösler and Christian W. Hess
2. The physiopathology of multiple sclerosis Giancarlo Comi
3. Synaptic changes in multiple sclerosis. Do they occur? How effectively can they be analyzed? Vincenzo Zimarino, Maddalena Ripamonti, Marcello Belfiore, Mattia Ferro and Antonio Malgaroli
4. Sodium channel expression and function in multiple sclerosis Lakshmi Bangalore, Joel A. Black, Michael D. Carrithers and Stephen G. Waxman
5. Basic mechanisms of functional recovery Björn Zörner and Martin E. Schwab
6. The adult human oligodendrocyte precursor cell: a key player in myelin repair Julia M. Rist and Robin J. M. Franklin
7. Tissue regeneration and repair in multiple sclerosis: the role of neural stem cells Stefano Pluchino, Roberto Furlan, Luca Muzio and Gianvito Martino
8. Schwann cells as a potential cell-based therapy for multiple sclerosis Violetta Zujovic and Anne Baron-Van Evercooren
Part II. Assessment of Mechanisms and Disease Status: 9. MRI to study white matter damage in multiple sclerosis Marco Rovaris, Annalisa Pulizzi and Massimo Filippi
10. MRI to assess gray matter damage in multiple sclerosis Massimo Filippi, Federica Agosta and Maria A. Rocca
11. Application of fMRI in multiple sclerosis Massimo Filippi and Maria A. Rocca
12. fMRI in focal CNS damage Patrizia Pantano and Eytan Raz
13. Electrophysiological assessment in multiple sclerosis Letizia Leocani and Giancarlo Comi
14. fMRI monitoring of therapeutic interventions in multiple sclerosis Massimo Filippi and Maria A. Rocca
Part III. Rehabilitation - General Aspects: 15. How to measure the effects of rehabilitation Stefan J. Cano and Alan J. Thompson
16. Value and limits of rehabilitation in multiple sclerosis Serafin Beer
17. Prognosis in neurorehabilitation Angelo Ghezzi and Annalisa Rizzo
18. Clinical trials to test rehabilitation Alessandra Solari
Part IV. Rehabilitation - Sectorial Interventions: 19. Spasticity in multiple sclerosis Mauro Zaffaroni
20. Cognitive rehabilitation in multiple sclerosis Dawn W. Langdon
21. Disorders of mood and affect in multiple sclerosis Anthony Feinstein and Omar Ghaffar
22. Bladder dysfunction in multiple sclerosis Clare J. Fowler and Gustav Kiss
23. Ataxia and imbalance in multiple sclerosis Luigi Tesio
24. Sexual problems in multiple sclerosis Per Olov Lundberg
25. Bulbar problems in multiple sclerosis Susan L. McGowan, Lucy Rodriguez and Clare Laing
26. Back home Carlo Pozzilli and Emanuela Onesti
Index.

Subject Areas: Neurology & clinical neurophysiology [MJN]