Multifaceted Role of IL-1 in Cancer and Inflammation

Presents all relevant information about the role of IL-1 in cancer growth, angiogenesis, immune suppression, resistance to immunotherapy, and more

Manisha Singh (Edited by)

9780128242735, Elsevier Science

Paperback, published 9 June 2023

192 pages, 30 illustrations (15 in full color)
22.9 x 15.2 x 1.4 cm, 0.45 kg

Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.

1. Role of IL-1 gene polymorphisms in common solid cancers Ragini D. Singh, Sagar Dholariya, Anusmita Shekher, Avadhesh, Deepak Parchwani and Subash C. Gupta 2. The role of IL-1 in tumor growth and angiogenesis Kinjal Bhadresha, Pradeep K. Shukla and Pratibha Singh 3. Interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer 4. Strategies to overcome interleukin-1-mediated immune suppression and resistance to immunotherapy in cancer Abhishek Puthenveetil, Shweta Dubey and Ankita Garg 5. Modulation of IL-1-mediated inflammation in cancer using a food-based approach: a preventive strategy Shubhi Singh, Smriti Gaur and Manisha Singh 6. IL-1-mediated inflammation in COVID-19 Preeti Jain, Baldeep Singh, Sadhna Aggarwal and Manisha Singh 7. Role of IL-1 in bacterial infections Aishwarya Rani and Devinder Toor

Subject Areas: Life sciences: general issues [PSA]