MRI-Negative Epilepsy
Evaluation and Surgical Management

This book critically appraises the role and value of specific diagnostic and treatment techniques for drug-resistant MRI-negative epilepsy.

Elson L. So (Edited by), Philippe Ryvlin (Edited by)

9781107034235, Cambridge University Press

Hardback, published 26 March 2015

255 pages, 18 b/w illus. 85 colour illus. 22 tables
25.5 x 19.5 x 1.5 cm, 0.74 kg

Drug-resistant epilepsy with negative MRI is frequently seen in patients considered for epilepsy surgery; however, clinical evaluation and surgical treatment is very complex and challenging. Advanced imaging techniques are needed to detect the location of the epileptogenic zone. In most cases, intracranial EEG recording is required to delineate the region of seizure onset - this carries some risks of major complications. Moreover, the borders between the recorded seizure onset and the location of important brain functions are often indistinct in MRI-negative epilepsy. Overall, the outcome of MRI-negative surgery is less favorable than that of MRI-positive surgery, but it can significantly improve with optimal management. Each chapter critically appraises the role and value of specific diagnostic and treatment techniques to address the challenges of MRI-negative epilepsy surgery. Authors critique evidence and share their expertise on the diagnostic options and surgical approaches that make epilepsy surgery possible and worthwhile in patients with this condition.

Preface
1. Scope and implications of MRI-negative refractory focal epilepsy Elson L. So and Philippe Ryvlin
2. Seizure semiology and scalp EEG in MRI-negative refractory focal epilepsy Soheyl Noachtar and Elisabeth Hartl
3. Clinical and advanced techniques for optimizing MRI in refractory focal epilepsy Neda Bernasconi and Andrea Bernasconi
4. PET in MRI-negative refractory focal epilepsy Alexander Hammers
5. Advanced SPECT image-processing in MRI-negative refractory focal epilepsy Elson L. So, Terence J. O'Brien and Benjamin H. Brinkmann
6. MEG and magnetic source imaging in MRI-negative refractory focal epilepsy Koji Iida, Akira Hashizume and Hiroshi Otsubo
7. Electric source imaging in MRI-negative refractory focal epilepsy Christoph M. Michel and Margitta Seeck
8. Functional MRI in MRI-negative refractory focal epilepsy Friederike Möller and Stephan Ulmer
9. Multimodality image co-registration for MRI-negative epilepsy surgery Benjamin H. Brinkmann and Vlastimil Sulc
10. Subdural electrode implantation and recording in MRI-negative epilepsy surgery Michael R. Sperling and Christopher T. Skidmore
11. Depth electrode and stereoelectroencephalography in MRI-negative epilepsy Philippe Ryvlin, Alexandra Montavont, Karine Ostrowsky-Coste and Marc Guénot
12. Ultraslow and high-frequency recordings in MRI-negative refractory focal epilepsy Vlastimil Sulc and Gregory A. Worrell
13. Cortical mapping in MRI-negative epilepsy surgery Gonzalo Alarcón and Antonio Valentín
14. Localization and surgery for MRI-negative temporal lobe and temporal-plus epilepsies Sang Kun Lee and Hyejin Moon
15. Localization and surgery in MRI-negative frontal lobe epilepsies Chathurbhuj Rathore and Kurapath Radhakrishnan
16. Localization and surgery in MRI-negative posterior cortical epilepsies Christoph Baumgartner and Susanne Pirker
17. MRI-negative refractory focal epilepsy in childhood Prasanna Jayakar and Michael Duchowny
18. Surgical approaches and techniques in MRI-negative focal epilepsy Sumeet Vadera and William Bingaman
19. Histopathology findings in MRI-negative focal epilepsy Ingmar Blümcke and Roland Coras
20. Neuropsychological issues in MRI-negative focal epilepsy surgery: evaluation and outcomes Rosana Esteller, Daniel L. Drane, Kimford J. Meador and David W. Loring
21. Conclusion Philippe Ryvlin and Elson L. So
Index.

Subject Areas: Surgery [MN], Radiology [MMPH], Neurology & clinical neurophysiology [MJN]