Monoclonal Antibodies

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.

Mary A. Ritter (Edited by), Heather M. Ladyman (Edited by)

9780521425032, Cambridge University Press

Paperback, published 26 January 1995

500 pages, 55 b/w illus. 38 tables
24.5 x 17 x 2.5 cm, 0.798 kg

'The editors have done a fine job. There is little redundancy between chapters, the text is clear and all the contributions are well referenced.' British Toxicology Society Newsletter

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject. Monoclonal antibodies provide highly specific reagents with which to identify, analyse, quantitate and manipulate molecules - both in solution and in solid phase, such as at a cell surface. The aim of this book is therefore to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications of these antibodies in many areas of clinical medicine, including histopathology, oncology, transplantation, infectious diseases, rheumatology, haematology and dermatology.

1. Introduction
2. Production of monoclonal antibodies
3. Antigen–antibody interactions: how affinity and kinetics affect assay design and selection procedures
4. The production and characterisation of synthetic peptide-derived antibodies
5. Human monoclonal antibodies
6. Bispecific monoclonal antibodies
7. The production of antibodies using phage display libraries
8. Genetic manipulation of monoclonal antibodies
9. Monoclonal antibodies in diagnostic immunoassays
10A. Monoclonal antibodies in diagnostic pathology
10B. In vivo targeting of monoclonal antibodies for immunoscintigraphy and therapy of human malignancies
11A. Monoclonal antibodies in infectious disease: diagnosis
11B. Monoclonal antibodies in the prophyllaxis and therapy of infectious disease
12A. Monoclonal antibodies in transplantation: immunohistology
12B. Monoclonal antibodies in transplantation: experimental studies on in vivo immunosuppression
12C. Monoclonal antibodies in transplantation: prophyllaxis of graft-versus-host disease after bone marrow transplantation
12D. Monoclonal antibodies in transplantation: use as therapeutic agents in clinical organ transplantation
13. Monoclonal antibodies and the skin
14. Monoclonal antibodies in endocrinology
15. Monoclonal antibodies in rheumatology
16. Technical appendix.

Subject Areas: Medical research [MBGR]