Molecular Targets in Protein Misfolding and Neurodegenerative Disease

An extensive reference on the molecular targets, disease-modifying chemical leads, and drugs that exist for neurodegenerative diseases, with a focus on Alzheimer’s, tauopathies, and other misfolding diseases.

Pierfausto Seneci (Author)

9780128001868, Elsevier Science

Hardback, published 9 October 2014

314 pages
22.9 x 15.1 x 2.3 cm, 1.26 kg

"...an excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars" --Doody's

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

1. Protein misfolding, neurodegeneration and Tau: The main players, or the usual suspects?2. Targeting the protein quality control (PQC) machinery: The neuronal Salvation Army3. Proteasomal degradation of soluble, misfolded proteins: Throwing out the bath water, but where’s the baby?4. Unselective disposal of cellular aggregates: Engulf, devour and digest to recycle5. Selective disposal of insoluble protein aggregates: Pick, transport and remove to cure6. Assembly and disassembly of protein aggregates: Unraveling the maze

Subject Areas: Molecular biology [PSD], Pharmacology [MMG], Neurology & clinical neurophysiology [MJN]