Molecular Mechanisms in Visual Transduction

D.G. Stavenga (Edited by), W.J. de Grip (Edited by), E.N. Pugh (Edited by)

9780444501028, Elsevier Science

Hardback, published 30 November 2000

596 pages
22.9 x 15.1 x 3.3 cm, 1.26 kg

Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are firstto determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.Since the 1940s [1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must beexplained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation aretreated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to

General preface. Preface to volume 3. Contents to volume 3. Contributors to volume 3.

Structure and mechanism of vertebrate visual pigments (W.J. DeGrip, K.J. Rothschild). The primary photoreaction of Rhodopsin (R.A. Mathies, J. Lugtenberg). Late photoproducts and signaling states of bovine Rhodopsin (K.P. Hofmann). Ion channels of vertebrate photoreceptors (R.S. Molday, U.B. Kaupp). Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification, recovery and light adaptation (E.N. Pugh Jr., T.D. Lamb). Comparative molecular biology of visual pigments (S.Yokoyama, R. Yokoyama). Invertebrate visual pigments (W. Gartner). Phototransduction mechanisms in microvillar and ciliary photoreceptors of invertebrates (E. Nasi, M. del Pilar Gomez, R. Payne). Genetic dissection of Drosophila phototransduction (B. Minke, R.C. Hardie). Modeling primary visual process in insect photoreceptors (D.G. Stavenga, J. Oberwinkler, M. Postma). Subject Index.

Subject Areas: Human biology [PSX], Animal physiology [PSVD], Biophysics [PHVN], Medical physics [PHVD]