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Molecular Diversity and Combinatorial Chemistry
Principles and Applications
Michael C. Pirrung (Author)
9780080444932, Elsevier Science
Hardback, published 11 September 2004
188 pages
24 x 16.5 x 1.9 cm, 0.49 kg
The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact. Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. Molecular Diversity and Combinatorial Chemistry emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field. The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.
Nature: The Original Combinatorial Chemist.Synthetic Peptide Libraries.Supports, Linkers, and reagents for Peptide Synthesis.Supports and Linkers for Small Molecule Synthesis.Encoded Combinatorial Chemistry.Directed Sorting.Unnatural Oligomers for Library Synthesis.Analytical Methods for Solid-phase Synthesis.Supported Solution-phase Synthesis.Solution-phase Parallel Synthesis.Multi-component Reactions.Chemical Informatics, Diversity, and Library Design.Nucleic Acid Microarrays.Combinatorial Materials Chemistry. Combinatorial Catalyst Discovery.Peptides on Phage.Nucleic Acid Selection.Complex Combinatorial and Solid-phase Synthesis.The Big Picture.
Subject Areas: Molecular biology [PSD], Genetics [non-medical PSAK], Organic chemistry [PNN], Spectrum analysis, spectrochemistry, mass spectrometry [PNFS], Pharmaceutical industries [KNDP]
