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Molecular Diagnostics
Exclusively dedicated to diagnosis of inherited diseases at the molecular level
George P. Patrinos (Edited by), Wilhelm Ansorge (Edited by)
9780125466615, Elsevier Science
Hardback, published 6 July 2005
488 pages
27.6 x 21.6 x 2.9 cm, 1.39 kg
"...the book is uniform in style. The text is free of jargon and is well written in an easy to understand style. ...This book is a great resource for experienced readers, giving them a wide overview of the most up-to-date methods. It is also a great book for students and medical professionals who want to learn about the molecular tools used in diagnostics. ...a great teaching aid for courses involving molecular biology, genetics and diagnostic techniques." --AUSTRALIAN BIOCHEMIST (April 2006)
"...the book will be useful to investigators in the diagnostic laboratory and to scientists generally who want a summary of current methods. ...Inclusion of ethical and safety considerations (as well as a section on patents) is a distinct plus, not often seen. ...this is a well organized and edited contribution." --DOODY'S (October 2005)
Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage.
Chapter 1: Molecular Diagnostics: Past, Present, and Future Section I: Molecular Diagnostic Technology Chapter 2: Allele-Specific Mutation Detection by PCR-ARMS and PCR-ASO Chapter 3: Competitive Oligopriming Chapter 4: Oligonucleotide Ligation Assays for the Diagnosis of Inherited Diseases Chapter 5: Enzymatic and Chemical Cleavage Methods to Identify Genetic Variation Chapter 6: Mutation Detection by Single Strand Conformation Polymorphism and Heteroduplex Analysis Chapter 7: Capillary Electrophoresis Chapter 8: Temperature and Denaturing Gradient Gel Electrophoresis Chapter 9: Two-Dimensional Gene Scanning Chapter 10: Real-Time Polymerase Chain Reaction Chapter 11: Pyrosequencing Chapter 12: Molecular Cytogenetics in Molecular Diagnostics Chapter 13: Detection of Genomic Duplications and Deletions Chapter 14: Analysis of Human Splicing Defects Using Hybrid Minigenes Chapter 15: DNA Microarrays and Genetic Testing Chapter 16: Human Genome Microarray in Biomedical Applications Chapter 17: Use of High Throughput Mass Spectrographic Methods to Identify Disease Processes Chapter 18: The Application of Proteomics to Disease Diagnostics Section II: Applications of Molecular Diagnostics and Related Issues Chapter 19: Identification of Genetically Modified Organisms Chapter 20: Pharmacogenetics and Pharmacogenomics: Impact on Drug Discovery and Development Chapter 21: Molecular Diagnostic Applications in Forensic Science Chapter 22: Molecular Diagnostics and Comparative Genomics in Clinical Microbiology Chapter 23: Preimplantation Genetic Diagnosis Chapter 24: Genetic Monitoring of Laboratory Animals Chapter 25: The Use of Locus-Specific Databases in Molecular Diagnostics Chapter 26: Safety Analysis in Retroviral Gene Therapy: Identifying Virus Integration Sites in Gene-Modified Cells Chapter 27: Automated DNA Hybridization and Detection Chapter 28: The Use of Microelectronic-Based Techniques in Molecular Diagnostic Assays Chapter 29: Miniaturization Technologies for Molecular Diagnostics Chapter 30: Human Gene Patents and Genetic Testing Chapter 31: Genetic Counselling and Ethics in Molecular Diagnostics Chapter 32: Genetic Testing and Psychology Chapter 33: Safety in Biomedical and Other Laboratories Chapter 34: Quality Management in the Laboratory
Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Immunology [MJCM], Medical diagnosis [MJA]
