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Molecular Diagnostics and Treatment of Pancreatic Cancer
Systems and Network Biology Approaches
Seeking to bridge the gap between basic researchers, bioinformaticians, and clinicians, this work introduces the concepts of cancer systems biology, systems medicine, and network pharmacology to study of the invariably terminal disease
Asfar Azmi (Author)
9780124081031, Elsevier Science
Hardback, published 17 April 2014
458 pages
22.9 x 15.1 x 2.8 cm, 0.93 kg
"...a well-written book on the use of cutting-edge technology in bioinformatics and computational modeling and how information from these assays can be used to discover new links between system elements in pancreatic cancer. Score: 77 - 3 Stars"--Doodys.com, January 30, 2015 "...describes the different emerging applications of systems biology that are shaping modern pancreatic cancer research...provides insights into important network evaluation methodologies related to microRNAs targetome..."--Anticancer Research, January 2015
Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.
1. An Integrated Systems Approach to the Study of Pancreatic Cancer2. Systems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance3. Proteomics of Pancreatic Cancer Stem Cells4. Systems and Network Guided Pancreatic Cancer Drugs5. Prioritizing Pancreatic Cancer Related miRNAs Using Systems Platform6. Pancreatic Proteome Guided Biomarker Discovery7. Proteomic Analysis of Pancreatic Biopsies8. RNAi Screen in Pancreatic Cancer Drug Development9. Modeling Apoptotic Signaling in Pancreatic Cancer10. Genetic, Epigenetic, and Proteomic Evaluation Post Laser Microdissection of Pancreatic Tumors11. Proteomic Analysis of Gemcitabine Toxicity12. Understanding Pancreatic Cancer through Proteomics of Stellate Cells in Rat Models13. Genome Wide CpG Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas14. Proteomic Profiling of Archival Lesions in Pancreatic Cancer15. Computational Assessment of Benign and Potentially Malignant Pancreatic Cysts16. Pancreatic Cancer Pharmacogenomics17. Systems Biology on Pancreatic Splice Variants18. Systems and Network for Pancreatic Cancer Drug Discovery
Subject Areas: Gastroenterology [MJH], Endocrinology [MJG], Oncology [MJCL]
