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Molecular Biological Markers for Toxicology and Risk Assessment
This professional reference provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. Covers a broad range of molecular biological markers, including the “omic” biomarkers, and provides an examination of the various elements in the evolution of these modern tools.
Bruce A. Fowler (Author)
9780128095898
Hardback, published 8 June 2016
164 pages
23.4 x 19 x 1.8 cm, 0.54 kg
Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.
Preface1. Introduction2. Historical Development of Biomarkers3. Computational Toxicology4. Omic Biological Markers5. Validation of Biological Markers for Epidemiological Studies6. Technical Translational Analysis of Biological Marker Data7. QA/QC of Biological Marker Data Sets8. Translation of Biomarkers for Human Clinical and Epidemiological Studies9. Risk Communication of Molecular Biological Marker Information10. Future Research DirectionsAppendices
Subject Areas: Molecular biology [PSD], Medical toxicology [MMGT], Public health & preventive medicine [MBN]
