Molecular Aspects of Host-Pathogen Interactions

Reports the latest advances in defining the molecular basis of infection in both bacterial and viral systems.

M. A. McCrae (Edited by), J. R. Saunders (Edited by), C. J. Smyth (Edited by), N. D. Stow (Edited by)

9780521592154, Cambridge University Press

Hardback, published 13 May 1997

373 pages
23.5 x 15.7 x 2.5 cm, 0.795 kg

'What a feast! This is a book which provides not only a series of comprehensive position papers on the state-of-the-art in one of the most rapidly developing - and trendy - areas in microbiology today, but a set of meaty reviews which should also be in the hands of those of us who dabble in other areas like molecular epidemiology and clinical microbiology. I strongly recommend my colleagues in these areas to read them if for nothing but the good of their souls!' Hugh Pennington, Society for General Microbiology Quarterly

An understanding of the relationship between a pathogen and its host is essential for the development of effective disease control measures. This volume focuses on interactions at the molecular level, specifically between the proteins of the infectious agent and the host that has been invaded. Both viral and bacterial systems are considered, with specific examples illustrating the rapid advances being made in defining the molecular mechanisms underlying infection.

1. Overview C. Chothia
2. Picornavirus receptors, tropism and pathogenesis D. J. Evans
3. Cross-talk between Yersinia and eukaryotic cells G. R. Cornelis
4. Host-pathogen protein-protein interactions in Staphylococcus T. J. Foster, O. Hartford and D. O'Connell
5. Mechanisms of microbial adhesion: the paradigm of Neisseriae M. Virji
6. Virus-host interactions in the control of the gene expression of nuclear replicating DNA viruses R. D. Everett
7. Regulation of human immunodeficiency virus gene expression Tat J. Karn, N. J. Keen, M. J. Churcher, F Aboul-Ela, G. Varani and M. J. Gait
8. Chlamydia host and host cell interactions M. Ward
9. Control of the fimbrial expression by a random genetic switch in Escherichia coli C. J. Dorman, N. C. Nolan and S. G. J. Smith
10. Virus and the protein synthesis machinery of the cell: Offense, defense and dependence M. B. Matthews
11. Shigella-induced cytoskeletal reorganisation during host cell invasion G. Tran Van Nhieu, T. Adams, C. Dehio, R. Ménard, A. Skoudy, J. Mounier, R. Hellio, P. Gounon and P. Sansonetti
12. Transport through plasmodesmata and nuclear pores: cell-to-cell movement of plant viruses and nuclear import of Agrobacterium T-DNA R. Lartey, S. Ghoshroy, J. Sheng and V. Citovsky
13. Viral cell recognition and entry M. Rossman
14. Enteropathogenic Escherichia coli and Salmonella species: exploitation of host cells? B. Finlay
15. Host-viral protein-protein in influenza virus replication P. Palese, P. Wang, T. Wolff and R E O'Neill
16. Transmissible spongiform encephalopathies and the formation of protease-resistant prion protein B. Caughey
Index.

Subject Areas: Microbiology [non-medical PSG]