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Modern Tools for the Synthesis of Complex Bioactive Molecules
Janine Cossy (Edited by), Stellios Arseniyadis (Edited by), Ei-ichi Negishi (Foreword by)
9780470616185, Wiley
Hardback, published 26 October 2012
608 pages
24.1 x 16.5 x 3.6 cm, 0.975 kg
All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.
FOREWORD vii CHAPTER 1 C–H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1 CHAPTER 2 THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES 33 CHAPTER 3 METAL-CATALYZED C–HETEROATOM CROSS-COUPLING REACTIONS 77 CHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111 CHAPTER 5 METATHESIS-BASED SYNTHESIS OF COMPLEX BIOACTIVES 155 CHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FOR THE SYNTHESIS OF BIOACTIVE MOLECULES 189 CHAPTER 7 ASYMMETRIC PHASE-TRANSFER CATALYSIS 213 CHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243 CHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS 271 CHAPTER 10 FLUOROUS LINKER-FACILITATED SYNTHESIS OF BIOLOGICALLY INTERESTING MOLECULES 335 CHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS 359 CHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES 395 CHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOID SYNTHESIS 433 CHAPTER 14 PRECURSOR-DIRECTED BIOSYNTHESIS OF POLYKETIDE AND NONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485 CHAPTER 15 TARGET-ORIENTED AND DIVERSITY-ORIENTED ORGANIC SYNTHESIS 513 CHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539 INDEX 557
PREFACE ix
CONTRIBUTORS xi
Sophie Rousseaux, Benoit Liegault, and Keith Fagnou
Evelina Colacino, Jean Martinez, and Frederic Lamaty
Renata Marcia de Figueiredo, Jean Marc Campagne, and Damien Prim
Fabien Gagosz
Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen
Mitsuru Shoji and Yujiro Hayashi
Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka
Jose Marco-Contelles and Elena Soriano
Lutz F. Tietze, Scott G. Stewart, and Alexander Dufert
Wei Zhang
Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and Steven V. Ley
Xavier Guinchard, Sebastien Picard, and David Crich
Scott Bur and Albert Padwa
Colin J. B. Harvey and Chaitan Khosla
Raphael Rodriguez
Michael Smietana, Jean-Jacques Vasseur, Janine Cossy, and Stellios Arseniyadis
Subject Areas: Chemistry [PN]
