Mitochondrial Neuropathies

Highlights mechanisms that are common to otherwise diverse conditions and identifies therapeutic approaches that broaden clinical applications

Nigel Calcutt (Volume editor), Paul Fernyhough (Volume editor)

9780128172247, Elsevier Science

Hardback, published 14 June 2019

252 pages
22.9 x 15.1 x 2.1 cm, 0.54 kg

Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation.

1. Mitochondriopathy: The unifying concept in distal neuropathies? Robert E. Schmidt 2. Dysfunction of mitochondria: Implications for Alzheimer's disease Benedict C. Albensi 3. HIV in the cART era and the mitochondrial: immune interface in the CNS Jerel Adam Fields and Ronald J. Ellis 4. Mitochondrial dysfunction in HIV-induced peripheral neuropathy Ricardo H. Roda and Ahmet Hoke 5. Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheral neuropathy Annalisa Trecarichi and Sarah J.L. Flatters 6. Disorders of mitochondrial dynamics in peripheral neuropathy: Clues from hereditary neuropathy and diabetes Amy E. Rumora, Masha G. Savelieff, Stacey A. Sakowski and Eva L. Feldman 7. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD⁺-dependent SIRT1–PGC-1a–TFAM pathway Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho and James W. Russell 8. Dichloroacetate-induced peripheral neuropathy Peter W. Stacpoole, Christopher J. Martyniuk, Margaret O. James and Nigel A. Calcutt

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN]