Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

A novel resource on the microbiome - metabolome - brain - vagus nerve circuit in various diseases

Elena L. Paley (Author)

9780443191220, Elsevier Science

Paperback / softback, published 26 January 2023

534 pages
23.5 x 19 x 3.3 cm, 1.06 kg

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.

1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve 2. COVID-19: Scientific progress 3. Viral-bacterial interactions in diseases 4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases 5. Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses 6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease 7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases 8. Crystalized aromatic l-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and l-DOPA (Levodopa or 3,4-dihydroxy-l-phenylalanine) 9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water 10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination 11. Smell and taste identification deficits in disease 12. Microorganisms producing biogenic amines: From food to human body 13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities? 14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms 15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens 16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases 17. Alzheimer’s disease, dementia, aging, and COVID-19 18. Existing vaccines and new and old tools 19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection 20. Circulating cell-free mitochondria and membrane vesicles 21. Protein synthesis inhibition in neuronal activities 22. Rosacea and associated medical disorders 23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens 24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome 25. Viral infections in vagus nerve 26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN], Physiology [MFG]