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Metals in Cells
Valeria Culotta (Edited by), V Culotta (Author), Robert A. Scott (Edited by)
9781119953234, Wiley
Hardback, published 27 September 2013
608 pages
28.7 x 22.4 x 3 cm, 1.901 kg
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Contributors xi Series Preface xix Volume Preface xxi PART 1: INTRODUCTION 1 Mechanisms Controlling the Cellular Metal Economy 3 PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15 Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39 Sparing and Salvaging Metals in Chloroplasts 51 Fluorescent Probes for Monovalent Copper 65 Fluorescent Zinc Sensors 85 X-Ray Fluorescence Microscopy 99 PART 3: MOVING METALS IN CELLS 111 Iron and Heme Transport and Trafficking 113 Iron in Plants 131 Transport of Nickel and Cobalt in Prokaryotes 145 Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155 Copper Transport in Fungi 163 Structural Biology of Copper Transport 175 Zinc Transporters and Trafficking in Yeast 183 Cadmium Transport in Eukaryotes 195 PART 4: METALS IN REGULATION 207 Metal Specificity of Metallosensors 209 Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225 Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related α-Proteobacteria 237 The Iron Starvation Response in Saccharomyces cerevisiae 249 Hepcidin Regulation of Iron Homeostasis 265 NikR: Mechanism and Function in Nickel Homeostasis 277 Regulation of Copper Homeostasis in Plants 289 Regulation of Zinc Transport 301 Selenoproteins—Regulation 311 PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321 Metals in Bacterial Pathogenicity and Immunity 323 Manganese in Neurodegeneration 335 Iron Sequestration in Immunity 349 Molecular Basis of Hemochromatosis 361 Copper in Brain and Neurodegeneration 373 Copper Transporting ATPases in Mammalian Cells 395 Copper in Immune Cells 409 Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421 Resistance Pathways for Metalloids and Toxic Metals 429 PART 6: COFACTOR ASSEMBLY 443 Fe–S Cluster Biogenesis in Archaea and Bacteria 445 Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters 473 [FeFe]-Hydrogenase Cofactor Assembly 491 [NiFe]-Hydrogenase Cofactor Assembly 507 Copper in Mitochondria 517 Mo Cofactor Biosynthesis and Crosstalk with FeS 529 Nitrogenase Cofactor Assembly 543 Index 555
Benjamin A. Gilston and Thomas V. O’Halloran
The Metallome 17
Vadim N. Gladyshev and Yan Zhang
Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson
Crysten E. Blaby-Haas and Sabeeha S. Merchant
M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni
Amy E. Palmer, Jose G. Miranda and Kyle P. Carter
James E. Penner-Hahn
Yvette Y. Yien and Barry H. Paw
Jessica B. Weng and Mary Lou Guerinot
Thomas Eitinger
Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins
Simon Labbe, Jude Beaudoin and Raphael Ioannoni
Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger
Yi-Hsuan Wu and David J. Eide
Nathan Smith, Wenzhong Wei and Jaekwon Lee
Khadine A. Higgins and David P. Giedroc
Zhen Ma and John D. Helmann
Mark R. O’Brian
Caroline C. Philpott and Pamela M. Smith
Clara Camaschella and Laura Silvestri
Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble
Marinus Pilon and Wiebke Tapken
Taiho Kambe
Lucia A. Seale and Marla J. Berry
Jennifer S. Cavet
Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner
Colin Correnti and Roland K. Strong
Paul J. Schmidt
Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White
Nan Yang and Svetlana Lutsenko
Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan
William Self and Sarah Rosario
Zijuan Liu, Christopher Rensing and Barry P. Rosen
Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten
Andrew Dancis and Paul A. Lindahl
Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick
Basem Soboh and R. Gary Sawers
Katherine E. Vest and Paul A. Cobine
Florian Bittner and Ralf R. Mendel
Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu
Subject Areas: Chemistry [PN]
