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Metalloenzymes
From Bench to Bedside
Offers a comprehensive overview of metalloenzymes and their catalytic sites, from biochemistry and structural features to pharmacology, drug-design, and biotechnological applications
Claudiu T. Supuran (Edited by), William Alexander Donald (Edited by)
9780128239742, Elsevier Science
Paperback / softback, published 15 September 2023
464 pages, 150 illustrations (100 in full color)
23.5 x 19 x 2.9 cm, 0.763 kg
Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications.
1. Introduction to metalloenzymes Section II 2. Magnesium and calcium-containing enzymes Section III 3. Zinc enzymes Section IV. Other metalloenzymes 4. Manganese enzymes 5. Nickel enzymes 6. Iron enzymes (heme-containing) 7. Iron enzymes (non-heme containing, Fe(II) or Fe(III) proteins) 8. Copper enzymes 9. Cadmium enzymes 10. Molybdenum enzymes 11. Tungsten-containing enzymes
