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Metabolic Syndrome and Neurological Disorders
Akhlaq A. Farooqui (Edited by), T Farooqui (Author), Tahira Farooqui (Edited by)
9781118395271, Wiley
Hardback, published 29 November 2013
576 pages
25.4 x 19.6 x 3 cm, 1.334 kg
Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians.
Foreword Mark P. Mattson xi Preface Tahira Farooqui and Akhlaq A. Farooqui xiii Acknowledgments Tahira Farooqui and Akhlaq A. Farooqui xv Contributors xvii 1 Insulin Resistance and Metabolic Failure Underlie Alzheimer Disease 1 2 Insulin Receptor and the Pathophysiology of Alzheimer Disease 31 3 Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease 51 4 Insulin–Leptin Signaling in the Brain 75 5 The Janus Face of Insulin in Brain 85 6 Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease 115 7 Contribution of Phospholipid, Sphingolipids, and Cholesterol-Derived Lipid Mediators in the Pathogenesis of Metabolic Syndrome and Neurological Disorders 137 8 Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated 9 Of Sound Mind and Body: Dietary Lifestyles, Promotion of Healthy Brain Aging, and Prevention of Dementia in Healthy Individuals 179 10 Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction 191 11 Neurochemical Linkage Among Metabolic Syndrome, Alzheimer Disease, and Depression 197 12 Alterations in the Endocannabinoid System as a Link Between Unbalanced Energy Homeostasis, Neuroinflammation, and Neurological and Neuropsychiatric Disorders 219 13 Metabolic Syndrome, Alzheimer Disease, Schizophrenia, and Depression: Role for Leptin, Melatonin, Kynurenine Pathways, and Neuropeptides 235 14 Binge Eating and Metabolic Syndrome 249 15 Phytochemical Principles in the Traditional Indian System of Medicine Used for the Management of Metabolic Syndrome 261 16 Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome 275 17 The Relationship Among Obesity, Inflammation, and Insulin Resistance 283 18 Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome 297 19 Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue 311 20 Is Diabetes a Risk Factor for Parkinson Disease? 327 21 Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome 335 22 Contributions of AMP Kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases 363 23 A_ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes 383 24 In Vivo Evidence of the Convergence of Type 2 Diabetes and Alzheimer Disease 395 25 Metabolic Syndrome and its Impact on Cardiovascular Disease 409 26 Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases 423 27 Brain and Cardiovascular Diseases: Molecular Aspects 439 28 Molecular Aspects of Dietary–Exercise Regimen for the Prevention of Metabolic Syndrome 461 29 Ghrelin, Lipid Metabolism, and Metabolic Syndrome 475 30 Leptin and Cognitive Function 485 31 Fructose, Sugar Consumption, and Metabolic Diseases 501 32 Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome 515 Index 539 Color plate section is located between pages 196 and 197.
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Neurotoxicity 163
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33 Summary and Perspective 529
Tahira Farooqui and Akhlaq A. Farooqui
Subject Areas: Biology, life sciences [PS]
