Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Covers the latest evidence on the commonalities of neurodegenerative disorders and metabolic disease

Grazyna Soderbom (Volume editor), Russell Esterline (Volume editor), Jan Oscarsson (Volume editor), Mark P. Mattson (Volume editor)

9780128231210, Elsevier Science

Hardback, published 25 August 2020

322 pages
22.9 x 15.1 x 2.4 cm, 0.63 kg

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more.

1. Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in neurodegenerative diseases
Kenneth Maiese
2. Antidiabetic drugs for Alzheimer´s and Parkinson´s diseases: Repurposing insulin, metformin and thiazolidinediones
Susana Cardoso and Paula I. Moreira
3. Evidence for pathophysiological commonalities between metabolic and neurodegenerative diseases
Christian Hölscher
4. Repurposing GLP1 agonists for neurodegenerative diseases
Ioanna Markaki, Kristian Winther, Sergiu-Bogdan Catrina and Per Svenningsson
5. A role for Sodium Glucose coTransporter 2 inhibitors (SGLT2i) in the treatment of Alzheimer's disease?
Russell Esterline, Jan Oscarsson and Jeffrey Burns
6. Ketotherapeutics for neurodegenerative diseases
Nicholas G. Norwitz, Javier Gilbert Jaramillo, Kieran Clarke and Adrian Soto
7. Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Yahyah Aman, Brent Ryan, Silje Bøen Torsetnes, Anne-Brita Knapskog, Leiv Otto Watne, William A. McEwan and Evandro Fei Fang
8. Cellular senescence in aging and age-related disorders: Implications for neurodegenerative diseases
Erin O. Wissler Gerdes, Yi Zhu, Bettina M. Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkonia and James L. Kirkland
9. Harnessing neurogenesis in the adult brain—A role in type-2-diabetes mellitus and Alzheimer’s disease
Orly Lazarov, Richard D. Minshall and Marcelo G. Bonini
10. Hormesis: A therapeutic strategic approach in the treatment of neurodegenerative disease
Edward J. Calabrese, Mark P. Mattson, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese and James Giordano

Subject Areas: Neurosciences [PSAN], Neurology & clinical neurophysiology [MJN]