Medicinal Chemistry
Fundamentals

Describes the fundamental concepts of Medicinal Chemistry, including physico-chemical properties (pKa, lipophilicity, solubility, polar surface), pharmacophore, Lipinsky parameters, and prodrugs

Roland Barret (Author)

9781785482885, Elsevier Science

Hardback, published 3 July 2018

172 pages
22.9 x 15.1 x 1.9 cm, 0.4 kg

Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia – the industrialist’s bible – its role, and a description of the monographs of active principles.

1. Medicines and Drugs 2. Importance and Evaluation of the pKa 3. Importance and Evaluation of Lipophilicity 4. Importance and Evaluation of Solubility 5. Importance and Evaluation of the Polar Surface Area (PSA and TPSA) 6. Lipinski’s Rule of Five 7. Principle of a Prodrug 8. Pharmacophore 9. The European Pharmacopoeia

Subject Areas: Pharmacology [MMG]