Medical Applications of Mass Spectrometry

A guide to help medical professionals understand mass spectrometry in clinical laboratories

Karoly Vekey (Edited by), Andreas Telekes (Edited by), Akos Vertes (Edited by)

9780444519801

Hardback, published 16 October 2007

606 pages
24 x 16.5 x 3.4 cm, 1.21 kg

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.

1. Introduction 2. Basics of analytical chemistry and mass spectrometry for medical professionals 3. Ethical, legal, safety and scientific aspects of medical research 4. Biomedical sampling 5. Separation methods 6. Mass spectrometry instrumentation and techniques 7. Cheminformatics: multivariate mathematical-statistical methods for data evaluation 8. Mass spectrometry in proteomics 9. De novo sequencing of peptides 10. Protein bioinformatics 11. Analysis of complex lipidomes 12. Medical laboratory practice - possibilities for mass spectrometry 13. Therapeutic drug monitoring 14. Mass spectrometry of infectious pathogens 15. Proteomics of viruses and their host partners 16. Neonatal diagnostics 17. Application of mass spectrometry in oncology
18 Application of mass spectrometry in brain research: neurotransmitters, neuropeptides and brain proteins 19. The human pituitary proteome: clinical applications 20. Mass spectrometry of proteinous allergens inducing human diseases 21. Mass spectrometry in clinical treatment 22. Biomarker discovery 23. Molecular imaging by mass spectrometry 24. Brief outlook

Subject Areas: Chemical engineering [TDCB], Physical chemistry [PNR], Organic chemistry [PNN], Spectrum analysis, spectrochemistry, mass spectrometry [PNFS], Analytical chemistry [PNF], Biophysics [PHVN]