Matrix Metalloproteinases

Robert P. Mecham (Series edited by), William C. Parks (Volume editor)

9780125450904, Elsevier Science

Hardback, published 27 March 1998

362 pages
22.9 x 15.2 x 2.5 cm, 0.68 kg

"It is an encyclopedia and up-to-date compendium of the minute details of the literature on all characterized MMPs for specialists in this field... would I buy it? Yes." --CELL

The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.

Contributors.
Preface.
The Matrix Metalloproteinase Family, J.F. Woessner, Jr..
Interstitial Collagenases, J.J. Jeffrey.
Stromelysins 1 and 2, H. Nagase.
72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson.
Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb.
Matrilysin, C.L. Wilson and L.M. Matrisian.
Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior.
Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy.
Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart.
Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown.
Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere.
Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff.
Index.

Subject Areas: Enzymology [PSBZ], Biochemistry [PSB], Pathology [MMF]