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Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Ragu Ramanathan (Edited by), R Ramanathan (Author)
9780471751588, Wiley
Hardback, published 16 January 2009
408 pages
24.1 x 16.3 x 2.4 cm, 0.68 kg
“All in all, the book delivers on its promises to introduce and review the current art of mass spectrometry for the related disciplines of drug metabolism and pharmacokinetics. I highly recommend it.” (JACS Book Reviews, June 2009) “In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics.” (Doody's, April 2009) "Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS. A wealth of information is provided and all of the contributing authors have done an excellent job in explaining and outlining particular aspects of MS-based tools in DMPK ... the book is highly recommended reading." (Journal of the American Society for Mass Spectrometry, March 2009)
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Preface vii About the Editor ix Contributors xi 1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1 2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87 3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123 4. Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening 159 5. Changing Role of FTMS in Drug Metabolism 191 6. High-Resolution LC–MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223 7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253 8. Online Electrochemical–LC–MS Techniques for Profiling and Characterizing Metabolites and Degradants 275 9. LC–MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine 295 10. Turbulent-Flow LC–MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311 11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341 12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359 Index 383
Dil M. Ramanathan and Richard M. LeLacheur
Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen
Elliott B. Jones
Jose M. Castro-Perez
Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders
Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray
Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and Don Walker
Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth
Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton
Joseph L. Herman and Joseph M. Di Bussolo
Jason S. Gobey, John Janiszewski, and Mark J. Cole
Yunsheng Hsieh and Walter A. Korfmacher
Subject Areas: Chemistry [PN]
