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Mass Spectrometry Handbook
Mike S. Lee (Edited by), MS Lee (Author)
9780470536735, Wiley
Hardback, published 25 May 2012
1368 pages
27.9 x 22.4 x 5.6 cm, 2.971 kg
“In summary, this handbook presents research from a variety of areas tied together by the common thread of mass spectrometry. The authors present their works in a manner that is accessible to beginning researchers and include sufficient references to allow in depth exploration of the topic. More seasoned scientists could also benefit from this book as they venture into new areas of research.” (Journal of American Society for Mass Spectrometry, 6 October 2012)
Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
FOREWORD xi PREFACE xiii CONTRIBUTORS xvii SECTION I BIOTECHNOLOGY/PROTEINS 1 1 Targeted Proteomics Using Immunoaffi nity Purifi cation 3 2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifi cations by Lipid Peroxidation Products 23 3 Imaging Mass Spectrometry (IMS) for Biological Application 41 4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs 85 SECTION II PHARMACEUTICAL 107 5 Preclinical Pharmacokinetics: Industrial Perspective 109 6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective 119 7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies 171 8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS 191 9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS 209 10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products 227 11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods 243 12 Accelerator Mass Spectrometry in Pharmaceutical Development 259 SECTION III CLINICAL ANALYSIS 271 13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism 273 14 Mass Spectrometry for Steroid Analysis 297 SECTION IV FORENSICS 339 15 Forensic Applications of Isotope Ratio Mass Spectrometry 341 16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry 373 SECTION V SPACE EXPLORATION 389 17 Mass Spectrometry in Solar System Exploration 391 18 Application of GC × GC–TOFMS to the Characterization of Extraterrestrial Organic Matter 407 SECTION VI HOMELAND SECURITY 417 19 Methods of Mass Spectrometry in Homeland Security Applications 419 20 Homeland Security 441 21 Mass Spectrometry in Homeland Security 477 22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer 491 23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios 509 SECTION VII FOOD ANALYSIS 529 24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications 531 25 Top-Down Proteomic Identifi cation of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS 559 SECTION VIII ENVIRONMENTAL 575 26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry 577 27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry 593 28 Proton Transfer Reaction Mass Spectrometry (PTR-MS) 605 29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices 631 SECTION IX GEOLOGICAL 645 30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions 647 31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology 675 32 Hydrocarbon Processing 707 33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples 725 34 Renewable Energy: Mass Spectrometry in Biofuel Research 749 SECTION X ARCHAEOLOGY 763 35 Mass Spectrometry in Archaeology 765 36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins, Lipids, Terpenoid Resins, Lignocellulosic Polymers, and Dyestuff 797 37 Laser Ablation ICP-MS in Archaeology 829 38 Spatially Resolved MS in the Study of Art and Archaeological Objects 845 39 Laser Ablation–Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples 859 SECTION XI SURFACE ANALYSIS 885 40 Mass Spectrometry in Semiconductor Research 887 41 Analysis of Thin and Thick Films 943 42 SIMS for Organic Film Analysis 961 43 Ceramics: Contribution of Secondary Ion Mass SECTION XII POLYMERS 1061 44 ETV-ICPMS for Analysis of Polymers 1063 45 Polymers 1079 46 Mass Spectroscopy in Polymer Research 1107 47 Laser Mass Spectrometry Applied to the Analysis of Polymers 1135 SECTION XIII ANALYTICAL TECHNIQUES 1143 48 Measuring Thermodynamic Properties of Metals and Alloys 1145 49 High-Performance Thin-Layer Chromatography–Mass Spectrometry for Analysis of Small Molecules 1181 50 Laser Ionization Mass Spectrometry of Inorganic Ions 1207 51 Mass Spectrometry in the SSITKA Studies 1229 52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences 1257 INDEX 1283
Karen R. Jonscher, Lei Jin, John C. Cambier, Shaikh M. Rahman, and Jacob E. Friedman
Navin Rauniyar and Laszlo Prokai
Yuki Sugiura, Ikuko Yao, and Mitsutoshi Setou
George W. Jackson, Rafal Drabek, Mithil Soni, Roger McNichols, Richard C. Willson, and George E. Fox
Ayman El-Kattan and Manthena Varma
Wenying Jian, Wilson Shou, Richard W. Edom, Naidong Weng, and Mingshe Zhu
Xiaoying Xu, Wenkui Li, and Francis L.S. Tse
Margrét Thorsteinsdóttir, Baldur Bragi Sigurðsson, and Gísli Bragason
Kevin A. Schug
Igor A. Kaltashov, Cedric E. Bobst, and Rinat R. Abzalimov
Satoka Aoyagi
Benjamin J. Stewart, Graham Bench, Bruce A. Buchholz, Kurt W. Haack, Michael A. Malfatti, Ted J. Ognibene, and Kenneth W. Turteltaub
Donald H. Chace
William J. Griffi ths, Michael Ogundare, Anna Meljon, and Yuqin Wang
Sarah J. Benson
Michael E. Sigman and C. Douglas Clark
Paul V. Johnson, Luther W. Beegle, and Isik Kanik
Jonathan S. Watson
Ünige A. Laskay, Erin J. Kaleta, and Vicki H. Wysocki
Christina L. Crawford and Herbert H. Hill, Jr.
Yasuaki Takada
Gary S. Groenewold, Anthony D. Appelhans, Garold L. Gresham, and John E. Olson
R. Steven Pappas
Maciej Stobiecki, Piotr Kachlicki, and Henryk Jeleñ
Clifton K. Fagerquist and Omar Sultan
Wolfgang Schwack
Chongzheng Na and Terese M. Olson
Yujie Wang, Chengyin Shen, Jianquan Li, Haihe Jiang, and Yannan Chu
Diana Poli
Simon C. George, Herbert Volk, and Adriana Dutkiewicz
Alain Cocherie and Michèle Robert
Maoqi Feng, Thomas Andrews, and Eloy Flores III
Alan A. Herod
Ingvar Eide and Kolbjørn Zahlsen
Robert Hedges and James McCullagh
Maria Perla Colombini, Francesca Modugno, and Erika Ribechini
Hector Neff
Giuseppe Spoto
Martín Resano, Esperanza García-Ruiz, and Frank Vanhaecke
Stefan Flege and Wolfgang Ensinger
Philippe Le Coustumer, Patrick Chapon, Agnès Tempez, Yuriy Popov, George Thompson, Igor Molchan, Nicolas Trigoulet, Peter Skeldon, Antonino Licciardello, Nunzio Tuccitto, Ivan Delfanti, Katrin Fuhrer, Marc Gonin, James Whitby, Markus Hohl, Christian Tanner, Nerea Bordel Garcia, Lara Lobo Revilla, Jorge Pisonero, Rosario Pereiro, Cristina Gonzalez Gago, Alfredo Sanz Medel, Mihai Ganciu Petcu, Ani Surmeian, Constantin Diplasu, Andreea Groza, Norbert Jakubowski, Roland Dorka, Stela Canulescu, Johann Michler, Philippe Belenguer, Thomas Nelis, Abdellatif Zahri, Philippe Guillot, Laurent Thérèse, Arnaud Littner, Richard Vaux, Julien Malherbe, Frédéric Huneau, Fred Stevie, and Hugues François-Saint-Cyr
Taoufi q Mouhib and Arnaud Delcorte
Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals 1017
Luisa Ottolini, Emanuela Schingaro, and Fernando Scordari
Maite Aramendía Marzo, Martín Resano, and Frank Vanhaecke
Maurizio S. Montaudo and Salvatore Battiato
Jale Hacaloglu and Talat Yalcin
Jérôme Bour and David Ruch
Evan H. Copland and Nathan S. Jacobson
Gertrud E. Morlock
Julius Pavlov and Athula B. Attygalle
L.G. Pinaeva, E.M. Sadovskaya, A.P. Suknev, V.B. Goncharov, and B.S. Bal’zhinimaev
Elena Crespo, Marco M.L. Steeghs, Simona M. Cristescu, and Frans J.M. Harren
Subject Areas: Chemistry [PN]
