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Mass Spectrometry for the Clinical Laboratory
Accessible guide to mass spectrometry and the evaluation, validation, and troubleshooting of the most common assays in clinical pathology labs
Hari Nair (Edited by), William Clarke (Edited by)
9780128008713, Elsevier Science
Hardback, published 22 November 2016
304 pages
23.4 x 19 x 2.3 cm, 0.79 kg
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab.
1. Mass spectrometry in clinical lab: determining the need and avoiding pitfalls 2. Application specific implementation of mass spectrometry platform 3. Sample preparation techniques for mass spectrometry in clinical lab: 4. Design of Validation and QC and Compliance 5. Best Practices for routine operation of clinical mass spectrometry assays 6. Toxicology: LCMS 7. Toxicology: GCMS 8. Therapeutic drug monitoring 9. Vitamin D and analogs 10. Steroid hormones 11. Thyroid hormones 12. Bacterial identification: MALDI TOF 13. High Resolution Accurate Mass (HRAM) Mass Spectrometry 14. Evolving platforms for clinical mass spectrometry (POCT, paper spray, TOF, etc)
Subject Areas: Organic chemistry [PNN], Spectrum analysis, spectrochemistry, mass spectrometry [PNFS], Pharmacology [MMG], Immunology [MJCM], Medical diagnosis [MJA]
