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Mass Spectrometry for Drug Discovery and Drug Development
Walter A. Korfmacher (Edited by), W Korfmacher (Author)
9780470942383, Wiley
Hardback, published 12 March 2013
480 pages
26 x 18.7 x 3.2 cm, 1.016 kg
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.
Contributors ix Preface xi 1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development 1 2 Utility of High-Resolution Mass Spectrometry for New Drug Discovery Applications 37 3 Quantitative Mass Spectrometry Considerations in a Regulated Environment 55 4 Mass Spectrometry for Quantitative In Vitro ADME Assays 97 5 Metabolite Identification Using Mass Spectrometry in Drug Development 115 6 MS Analysis of Biological Drugs, Proteins, and Peptides 149 7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics 191 8 Liquid Extraction Surface Analysis (LESA): A New Mass Spectrometry-Based Technique for Ambient Surface Profiling 221 9 MS Applications in Support of Medicinal Chemistry Sciences 239 10 Imaging Mass Spectrometry of Proteins and Peptides 277 11 Imaging Mass Spectrometry for Drugs and Metabolites 303 12 Screening Reactive Metabolites: Role of Liquid Chromatography–High-Resolution Mass Spectrometry in Combination with “Intelligent” Data Mining Tools 339 13 Mass Spectrometry of siRNA 357 14 Mass Spectrometry for Metabolomics 387 15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High-Resolution Full Scan? 403 Index 427
Gérard Hopfgartner
William Bart Emary and Nanyan Rena Zhang
Mohammed Jemal and Yuan-Qing Xia
Jun Zhang and Wilson Z. Shou
Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash
Yi Du, John Mehl, and Pavlo Pristatsky
Hui Wei, Guodong Chen, and Adrienne A. Tymiak
Daniel Eikel and Jack D. Henion
Maarten Honing, Benno Ingelse, and Birendra N. Pramanik
Michelle L. Reyzer and Richard M. Caprioli
Stacey R. Oppenheimer
Shuguang Ma and Swapan K. Chowdhury
Mark T. Cancilla and W. Michael Flanagan
Petia Shipkova and Michael D. Reily
Lieve Dillen and Filip Cuyckens
Subject Areas: Chemistry [PN]
