Managing Treatment-Resistant Depression
Road to Novel Therapeutics

Discusses the neurobiology underlying depression with a comprehensive summary of the most recent advances in research and cutting-edge treatments

Joao Quevedo (Edited by), Patricio Riva-Posse (Edited by), William V. Bobo (Edited by)

9780128240670, Elsevier Science

Paperback, published 4 April 2022

612 pages, 35 illustrations (10 in full color)
27.6 x 21.6 x 3.8 cm, 0.45 kg

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

1. Defining treatment-resistant depression, difficult-to-treat depression, and staging treatment intensity
2. Clinical and epidemiological predictors of treatment-resistant depression
3. The economic burden of treatment-resistant depression: Cost-of-illness perspective
4. The neurobiology of treatmentresistant depression
5. Modeling treatment-resistant depression in the preclinical setting
6. Treatment algorithms for treatment-resistant depression
7. Tools to aid precision treatments to prevent or manage treatmentresistant depression (TRD): Pharmacogenomics, machine learning, and artificial intelligence
8. Tricyclic antidepressants for treatment-resistant depression
9. Monoamine oxidase inhibitors for treatment-resistant depression
10. Switching antidepressants in patients with treatment-resistant depression
11. Adjunctive strategies for treatment-resistant depression
12. Combining antidepressants to address treatment-resistant depression
13. Ketamine/esketamine for treatment-resistant depression
14. Psychedelic agents for treatmentresistant depression
15. Inflammation and treatment resistance: Mechanisms and treatment implications
16. Opioid agents for treatmentresistant depression
17. Transcranial magnetic stimulation for treatment-resistant depression
18. tDCS for treatment-resistant depression
19. ECT for treatment-resistant depression
20. MST for treatment-resistant depression
21. VNS for treatment-resistant depression
22. Deep brain stimulation for treatment-resistant depression
23. Other neurosurgical interventions for treatment-resistant depression
24. Treatment-resistant psychotic depression
25. Evidence-based psychotherapy for treatment-resistant depression
26. Treatment-resistant bipolar depression
27. Treatment-resistant depression in child and adolescents
28. Treatment-resistant depression in geriatrics
29. Identification and management of anxious depression in patients with treatment-resistant depression
30. Managing treatment-resistant depression with comorbid personality disorders
31. Managing treatment-resistant depression with comorbid substance use disorders
32. Managing treatment-resistant depression in the setting of chronic pain
33. Inhaled gases for treatmentresistant major depression
34. Drugs under investigation for treatment-resistant depression
35. Chronotherapeutics for treatmentresistant depression
36. Managing treatment resistant depression in primary care settings
37. Treatment-resistant depression in pregnancy, the postpartum period, and transition to menopause
38. Lifestyle interventions for treatment-resistant depression
39. Managing the risk of suicide in people with treatment-resistant depression
40. Maintaining motivation and preserving the therapeutic alliance as tools to overcome treatmentresistant depression

Subject Areas: Neurosciences [PSAN], Pharmacology [MMG], Endocrinology [MJG], Immunology [MJCM]