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Magnetic Resonance Spectroscopy
Tools for Neuroscience Research and Emerging Clinical Applications
The only book targeted at neuroscientists and clinicians that covers all aspects of the MRS technique and its applications
Charlotte Stagg (Edited by), Douglas L. Rothman (Edited by)
9780124016880, Elsevier Science
Hardback, published 17 January 2014
398 pages
27.6 x 21.5 x 2.6 cm, 1.29 kg
"Specialists in the neurosciences and in Magnetic Resonance Specctroscopy technology present a reference of the imaging technology for neurologists, psychiatrists, radiologists, and neuroscientists…The areas covered are technical aspects - how MRS is acquired, biochemistry - what underlies the signal, and applications of proton and non-proton MRS." --ProtoView.com, April 2014
Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective.
Section 1: Technical Aspects - How MRS Is Acquired 1.1 Basis of Magnetic Resonance 1.2 Localized Single-Voxel Magnetic Resonance Spectroscopy, Water Suppression, and Novel Approaches for Ultrashort Echo-Time Measurements 1.3 Technical considerations for Multivoxel Approaches and Magnetic Resonance Spectroscopic Imaging 1.4 Spectral Editing and 2D NMR 1.5 Spectral Quantification and Pitfalls in Interpreting Magnetic Resonance Spectroscopic Data: What to Look Out For Section 2: Biochemistry - What Underlies the Signal? 2.1 N-Acetylaspartate and N-Acetylaspartylglutamate in Central Nervous System Health and Disease 2.2 The Biochemistry of Creatine 2.3 The Biochemistry of Choline 2.4 Glutamate 2.5 Other Significant Metabolites: Myo-Inositol, GABA, Glutamine, and Lactate Section 3: Applications of Proton-MRS 3.1 Usefulness of Proton Magnetic Resonance Spectroscopy in the Clinical Management of Brain Tumors 3.2 Multiple Sclerosis and Inflammatory Diseases 3.3 Epilepsy 3.4 Stroke and Cerebral Ischaemia 3.5 Use of MRS in Inborn Errors of Metabolism: Canavan’s Disease and MRS in Differential Diagnosis 3.6 MRS of Psychiatric Disorders 3.7 Preclinical and Clinical Applications of 1H-MRS in the Spinal Cord 3.8 Interindividual Differences in Behavior and Plasticity 3.9 MRS in Development and Across the Lifespan 3.10 Hormonal Influences on Magnetic Resonance Spectroscopy Measures 3.11 Magnetic Resonance Spectroscopy in Neuroenergetics and Neurotransmission Section 4: Applications of Non-Proton MRS 4.1 Quantitative Metabolic Magnetic Resonance Imaging of Sodium, Oxygen, Phosphorus, and Potassium in the Human Brain: A Rationale for Bioscales in Clinical Applications 4.2 Carbon (13C) MRS 4.3 Hyperpolarized Magnetic Resonance Imaging and Spectroscopy of the Brain
Subject Areas: Medical imaging [MMP], Neurology & clinical neurophysiology [MJN]
