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Lysophospholipid Receptors
Signaling and Biochemistry

Jerold Chun (Edited by), J Chun (Author), Timothy Hla (Associate editor), Sarah Spiegel (Associate editor), Wouter Moolenaar (Associate editor)

9780470569054, Wiley

Hardback, published 10 May 2013

812 pages
24.1 x 16.5 x 4.4 cm, 1.306 kg

The current state of the science supporting new research in lysophospholipids

The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling.

Lysophospholipid Receptors is divided into three sections:

  • Receptors and other possible effectors
  • Enzymes
  • Physiology and pathophysiology

Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics.

Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

PREFACE ix

CONTRIBUTORS xi

1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1
Hope Mirendil, Mu-En Lin, and Jerold Chun

2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41
Bongnam Jung and Timothy Hla

3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61
Catelijne Stortelers and Wouter H. Moolenaar

4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71
Nitai C. Hait, Sheldon Milstien, and Sarah Spiegel

5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE–G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85
Nigel J. Pyne and Susan Pyne

6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103
Hiroshi Yukiura and Junken Aoki

7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121
Masayuki Masu, Seiichi Koike, Takuya Okada, and Kazuko Keino-Masu

8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY 137
Jeff D. Moore, Shengrong Li, David S. Myers, Stephen B. Milne, H. Alex Brown, and Walter A. Shaw

9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153
Melissa R. Pitman, Kate E. Jarman, Tamara M. Leclercq, Duyen H. Pham, and Stuart M. Pitson

10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185
Atsuo Kawahara and Tsuyoshi Nishi

11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201
Ganesh Venkatraman and David N. Brindley

12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229
Andrew J. Morris, Susan S. Smyth, Abdel K. Salous, and Andrew D. Renault

13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265
Susan S. Smyth, Anping Dong, Jessica Wheeler, Manikandan Panchatcharam, and Andrew J. Morris

14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND DISEASE 283
Bodo Levkau

15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313
Christian Waeber

16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPARγ BY ENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349
Ryoko Tsukahara, Tamotsu Tsukahara, and Gabor Tigyi

17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE 1-PHOSPHATE (S1P) 373
Shigeki Miyamoto, Sunny Yang Xiang, Nicole H. Purcell, and Joan Heller Brown

18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399
Nobuyuki Fukushima

19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419
H. Meng and V.M. Lee

20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA BIOSYNTHESIS 433
Hiroshi Ueda

21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES: IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451
Guillermo Estivill-Torrús, Luis Javier Santín, Carmen Pedraza, Estela Castilla-Ortega, and Fernando Rodríguez de Fonseca

22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475
Alejandra Mendoza, Lauren A. Pitt, and Susan R. Schwab

23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED MICE 489
Maria L. Allende, Mari Kono, Aikaterini Alexaki, Christina Giannouli, Jiman Kang, Catherine C. Theisen, Eleanor L. Koerner, and Richard L. Proia

24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507
C. Chris Yun and Peijian He

25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529
Xiaoqin Ye

26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 569
Lygia Therese Budnik, Bärbel Brunswig-Spickenheier, and Dieter Müller

27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587
Barry S. Shea and Andrew M. Tager

28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609
Jean Pierre Salles, Sara Laurencin-Dalicieux, Françoise Conte-Auriol, Fabienne Briand-Mésange, and Isabelle Gennero

29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627
Olivier Peyruchaud, Marion David, Timothy L. Macdonald, and Kevin R. Lynch

30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 641
Nattapon Panupinthu and Gordon B. Mills

31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661
Abir Mukherjee, Jinhua Wu, Yongling Gong, and Xianjun Fang

32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681
Gretchen Bain and T. Jon Seiders

33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN ASSAYS 709
Yutaka Yatomi, Koji Igarashi, Kazuhiro Nakamura, Ryunosuke Ohkawa, Akiko Masuda, Akiko Suzuki, Tatsuya Kishimoto, Hitoshi Ikeda, and Junken Aoki

34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737
Roger A. Sabbadini, Jonathan M. Wojciak, Kelli Moreno, James S. Swaney, and Barbara Visentin

INDEX 753

Subject Areas: Chemistry [PN]
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