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Ligand Efficiency Indices for Drug Discovery
Towards an Atlas-Guided Paradigm
A guided 'mini-atlas' of the content of Chemico-Biological Space with snapshots, postcards and views of the chemistry and biology related to pharmacology, medicine and drug-discovery
Celerino Abad-Zapatero (Author)
9780124046351
Paperback, published 28 January 2013
178 pages, 25 illustrations (25 in full color)
22.9 x 15.1 x 1.3 cm, 0.39 kg
"For those interested in a fresh interpretation of the utility of ligand efficiency indexes for drug discovery, this book serves as a nice introduction to a more modern, graphical approach to drug lead identification." --Doody.com, August 16, 2013 "Abad-Zapatero presents a novel approach to drug discovery that is based on the notion that a change of variables is necessary. The algebraic framework he proposes combines the affinity between ligands and targets with the physico-chemical properties of the ligands to construct a set of novel variables that can map chemico-biological space (CBS) and optimize the drug-discovery process." --Reference and Research Book News, August 2013
Approx.162 pages
IntroductionPART 1: The Elements: Data, Variables, Concept and the ServerPART 2: Conceptual Applications of the AtlasCBS: A New ParadigmPART 3: Exploring CBS: Practical Examples Using the AtlasCBS ServerReferencesEpilogueAppendix I. Appendix II.
Subject Areas: Biotechnology [TCB], Organic chemistry [PNN], Medical toxicology [MMGT], Pharmacology [MMG]
