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Life-Threatening Effects of Antipsychotic Drugs
This book is an essential reference text for psychiatrists, pathologists and any physician treating a psychiatric patient with a life-threatening condition. It would also be useful to primary care physicians with patients taking antipsychotic medication.
Peter Manu (Edited by), Robert J. Flanagan (Edited by), Kathlyn J. Ronaldson (Edited by)
9780128033760, Elsevier Science
Hardback, published 16 August 2016
394 pages
22.9 x 15.1 x 2.6 cm, 0.77 kg
"… this book …presents important evidence-based information on side effects of antipsychotic drugs and how to prevent and counteract these. The book is organized in seven parts, all of them dealing with adverse effects of antipsychotic drugs in different organ systems: cardiovascular adverse effects, haematological complications, the digestive system, neurological and neuromuscular, metabolic complications, other life-threatening effects such as interstitial diseases in kidney and lung and, finally, a chapter dealing with clinical and forensic challenges in the use of antipsychotic drugs. All subjects are treated in a consistent manner, starting with an epidemiological overview, followed by some background regarding pathobiology, continuing over clinical signs to management, ending up with suggestions for prevention of the conditions. The book has a richness of tables and figures facilitating the reading and understanding of the book’s important information and many messages of, e.g. Hazard ratios, odds ratios, clinical algorithms, all making it easily accessible. … The book is highly relevant to the clinically working psychiatrist, his/her assistants, medical students and other with interest in the interphase between psychiatric illnesses, somatic diseases, their treatment and the always present balance between effect and side effects of treatments." --Mikkel Hojlund, Povl Munk-Jørgensen, Nordic Journal of Psychiatry
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.
Part I: Cardiovascular Adverse Effects of Antipsychotic Drugs Chapter 1 - Sudden Cardiac Death and Ventricular Arrhythmias Peter Manu, Anca Dan and Gheorghe-Andrei Dan Chapter 2 - Myocarditis and Cardiomyopathy Kathlyn J. Ronaldson Chapter 3 - Pulmonary Embolism Peter Manu, Christopher Hohman, James F. Barrecchia, and Matisyahu Shulman Chapter 4 - Orthostatic Hypotension James J. Gugger and Megan J. Ehret Part II: Hematological Complications of Treatment With Antipsychotic Drugs Chapter 5 - Severe Neutropenia and Agranulocytosis John Lally and Robert J. Flanagan Part III: Antipsychotic-Related Pathology of the Digestive System Chapter 6 - Gastrointestinal Hypomotility and Dysphagia Robert J. Flanagan and Kathlyn J. Ronaldson Chapter 7 - Liver Failure Katie F.M. Marwick 8. Pancreatitis Peter Manu, Matisyahu Shulman and Kathlyn J. Ronaldson Part IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic Drugs Chapter 9 - Seizures Tilman Steinert and Walter Fröscher Chapter 10 - Neuroleptic Malignant Syndrome Julie Langan Martin and Daniel J. Martin Chapter 11 - Heat Stroke and Rhabdomyolysis Kathlyn J. Ronaldson Part V: Metabolic Complications of Antipsychotic Drug Treatment Chapter 12 - Type 2 Diabetes Mellitus Davy Vancampfort, Richard I.G. Holt, Brendon Stubbs, Marc De Hert, Katherine Samaras and Alex J. Mitchell Part VI: Other Life-Threatening Effects of Antipsychotic Drugs Chapter 13 - Interstitial Nephritis and Interstitial Lung Disease Kathlyn J. Ronaldson Part VII: Clinical and Forensic Challenges in the Use of Antipsychotic Drugs Chapter 14 - The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of Life Jian-Ping Zhang Chapter 15 - Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical Management Dan Cohen Chapter 16 - Forensic Investigation of Antipsychotic-Related Deaths Robert J. Flanagan and Peter Manu
Subject Areas: Psychopharmacology [MMGW]
