Joint and Bone
From Bench to Bedside

Overviews the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics in the joint and bone

Deming Jiang (Edited by), Ahmed El-Hashash (Edited by)

9780323919388, Elsevier Science

Paperback / softback, published 2 February 2023

246 pages, 30 illustrations (20 in full color)
23.5 x 19 x 1.7 cm, 0.45 kg

Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside.

Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.

1. Cutting edge research on stem cell applications in joint and bone repair and regeneration
2. Stem Cell-Based Organoid culture system as innovative model of osteoarthritis and other joint/bone diseases
3. Contributions of stem cell engineering to new therapies of joint/bone diseases
4. Roles of innovative genome editing technologies (e.g. CRISPR/Cas9 systems) in stem cell engineering, rheumatic diseases and other joint/bone diseases
5. Preclinical and clinical applications of iPSC technology in modeling osteoarthritis pathologies and testing drugs
6. The gold standard iPSCs in cartilage, joint and bone repair and regeneration
7. Mesenchymal stem cell related therapies for cartilage, joint and bone diseases
8. Advances in animal models for joint and bone diseases
9. Novel Biomaterials for stem cell engineering and bone regeneration
10. General Discussion, Conclusion Remark and Future Direction

Subject Areas: Life sciences: general issues [PSA]