Ion Channels
Molecules in Action

Up-to-date introduction to ion channels and how they work, emphasising their molecular structure.

David J. Aidley (Author), Peter R. Stanfield (Author)

9780521498821, Cambridge University Press

Paperback, published 13 August 1996

320 pages, 132 b/w illus. 20 tables
24.6 x 18.9 x 1.7 cm, 0.573 kg

' … a very good, balanced overview of the structure and function of such channels.' Nature

Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.

Preface
1. Introduction
2. Ions on the move
3. Investigating channel activity
4. Molecular structures
5. Permeability and selectivity
6. Gating and modulation
7. Drugs and toxins
8. Dysfunctional channels in human disease
9. Not the last word
References
Index.

Subject Areas: Animal physiology [PSVD], Biochemistry [PSB], Neurosciences [PSAN]