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Investigating Human Diseases with the Microbiome
Metagenomics Bench to Bedside
Contains comprehensive coverage of the human microbiome for everyone who is interested in this rapidly growing field
Huijue Jia (Author)
9780323913690, Elsevier Science
Paperback / softback, published 28 February 2022
226 pages
23.5 x 19 x 1.5 cm, 0.5 kg
Investigating Human Diseases with the Microbiome: Metagenomics Bench to Bedside is a summary of underlying principles for human health and disease studies from a microbiome point-of-view. From birth to old age, microbiomes in fecal, oral/nasal, vaginal, and skin samples contain important information that can predict disease risks in the future. Tissue samples also contain microbes that are relevant for diseases. The microbiome connects genetic and environmental factors and is poised to greatly facilitate precision medicine, including prevention, diagnosis and effective treatment of many complex diseases. Based in traditional microbiology and adding a more wholistic view of the advent of high-throughput sequencing, this reference poses the key questions of the total number of microbial cells and their distribution in the human body while also considering concepts from macroecology and from causal reasoning. An entire chapter is dedicated to methods, providing hands-on information for important considerations when collecting samples for metagenomic studies.
1. The Supraorganism 2. Microbiota 3. Collecting samples for metagenomics 4. Epidemiology for the human body 5. The evolving microbial taxonomy 6. Blurring the line between opportunistic ‘pathogens’ and ‘commensals’ 7. Metagenomics from bench to bedside and from bedside to bench 8. A Microbiome record for life
Subject Areas: Life sciences: general issues [PSA]
