Introductory Review on Sirtuins in Biology, Aging, and Disease

Comprehensive coverage on the functionality of the diverse family of sirtuins proteins and their use in biology and disease

Leonard Guarente (Edited by), Raul Mostoslavsky (Edited by), Aleksey Kazantsev (Edited by)

9780128134993

Paperback, published 25 April 2018

220 pages
23.5 x 19 x 1.5 cm, 0.48 kg

Approx.202 pages

1. Early Sirtuin Research 1991-2000 2. Regulation of sirtuins by systemic NAD+ biosynthesis 3. NAD modulation - biology and therapy 4. The enzymatic activity of sirtuins 5. Molecular mechanisms of Sirtuin activation and inhibition 6. Pharmacological approaches for modulating sirtuins 7. Mitochondrial Sirtuins 8. Biological Roles and Activities for Mitochondrial Sirtuins 9. The multitasking roles of the mammalian deacetylase SIRT6 10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond 11. Sirtiuns and Carcinogenesis 12. Roles for sirtuins in cardiovascular biology 13. Sirtuins in Brain Biology and Disease

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD], Genetics [non-medical PSAK]