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Intestinal Failure
Diagnosis, Management and Transplantation

Alan Langnas (Edited by), A Langnas (Author), Olivier Goulet (Edited by), Eamonn M. M. Quigley (Edited by), Kelly A. Tappenden (Edited by)

9781405146371, Wiley

Hardback, published 15 February 2008

416 pages
25.4 x 19.6 x 2.7 cm, 1.17 kg

"This is a useful, comprehensive, practical guide to modern assessment and management of complex intestinal failure cases. The book was compiled by experienced clinicians resulting in an authoritative, novel resource on intestinal failure." (Doody's Reviews, March 2009)

"A comprehensive overview of the far-reaching effects of loss of the gut. It is a good update on state-of-the-art treatment of patients...and the authors also go behind the scenes to discuss aspects of care.... Intestinal Failure gives insight into recent progress in the understanding of intestinal failure, covers the most important topics that the clinician working in this area will face.... Despite major improvements in the survival of patients with severe intestinal failure, the treatment of patients with poor gut function remains an exciting and challenging area of medicine, and this book enables the reader to have a good overview and understanding of the topic." (New England Journal of Medicine, November 2008)

Intestinal failure is a challenging, emerging field that has been the subject of much research and debate in recent years and has only recently become widely accepted as a distinct clinical syndrome.

This comprehensive book provides an in-depth review of scientific theory and clinical practice relating to intestinal failure with specific emphasis on assessment and management as part of a multidisciplinary team. Compiled by an internationally recognised editorial team, the book provides a practical how-to guide to the management of adult and pediatric patients with intestinal failure, focusing on quality-of-life issues that are at the heart of patient care.

  • World experts from centers of excellence share their clinical experience and expertise, offering the first ever authoritative resource on intestinal failure
  • All aspects of patient management are covered, from diagnosis and medical and surgical management (including transplantation) to nutritional consideration and psychosocial aspects of care
  • Numerous illustrations, flow diagrams and summary boxes complement the text and emphasize important concepts, providing an accessible approach to this complex field

This landmark book is essential reading for any gastroenterologists, surgeons, transplant teams or clinical nutritionists involved in the care of patients with intestinal failure.

List of Contributors, viii
Foreword, xiii
Preface, xvii
Abbreviations, xix

Part 1 Introduction

1 The History of Intestinal Failure and Transplantation, 3
Alan N. Langnas

Part 2 Intestinal Physiology and Immunology

2 Intestinal Morphology, Intestinal Regeneration and the Promise of Tissue Engineering, 13
David A.J. Lloyd and Simon M. Gabe

3 Basic Physiology of Motility, Absorption and Secretion, 20
Greger Lindberg

4 Immunology of the Small Intestine, 33
Liam O'Mahony

5 Intestinal Adaptation: The Biology of the Intestinal Response to Resection and Disease, 45
Marc S. Levin and Deborah C. Rubin

Part 3 Intestinal Failure: Definition and Pathophysiology

6 Intestinal Failure: Definitions and Classifications, 57
Dominique M. Jan

7 Causes of Intestinal Failure in the Newborn, 66
Yigael Finkel

8 Congenital Enteropathies Causing Permanent Intestinal Failure, 77
Olivier Goulet

9 Causes of Intestinal Failure in the Adult, 88
Harry C. Sax

10 Intestinal Failure Related to Bariatric Surgery, 93
Jon S. Thompson

11 Inflammatory Bowel Disease and the Short Bowel Syndrome, 99
Ramsey K. Umar and Alan L. Buchman

12 Motility Disorders, 107
Hayat Mousa and Carlo Di Lorenzo

Part 4 Assessment and General Management of Intestinal Failure

13 Assessment of Intestinal Failure Patients, 117
Clarivet Torres

14 Guidelines for Home Parenteral Nutrition Support in Chronic Intestinal Failure Patients, 122
Bernard Messing, Francisca Joly and Virginie Colomb

15 Home Parenteral Nutrition: Complications, Survival, Costs and Quality of Life, 130
John K. DiBaise

16 Vascular Access, Including Complications, 142
Sanja Kola¡cek and Julije Me¡strovi´c

17 Enteral Support for Children with Intestinal Failure, 151
Daniel S. Kamin and Christopher Duggan

18 The Use of Enteral Nutrition in the Adult with Intestinal Failure, 160
Khursheed N. Jeejeebhoy

19 The Enteric Flora in Intestinal Failure: Small Intestinal Bacterial Overgrowth and Gut-Derived Sepsis, 167
Eamonn M.M. Quigley, Rodrigo Quera and Ahmed Abu-Shanab

20 Management of Complex Fluid and Electrolyte Disturbances, 185
Stuart S. Kaufman and Erin M. Fennelly

21 Intestinal Failure-Associated Liver Disease, 191
Sue V. Beath and Jeremy M. Woodward

22 Psychiatric Issues in the Assessment of the Patient with Intestinal Failure, 201
James H. Sorrell

23 Munchausen Syndrome by Proxy, 206
Paul E. Hyman and Brenda Bursch

Part 5 Pharmacological Approaches to Intestinal Failure

24 Luminal Nutrient Factors in Intestinal Adaptation and Their Use in Therapy, 215
Jon A. Vanderhoof and Rosemary J. Young

25 The Role of Humoral Factors in Intestinal Adaptation, 223
Jennifer N. Woodard and Kelly A. Tappenden

Part 6 Autologous Reconstruction of the GI Tract

26 Autologous Reconstruction of the GI Tract, 231
Debra Sudan

Part 7 Organ Replacement Therapy for Intestinal Failure

27 Intestinal Transplantation: Indications and Patient Selection, 245
Kareem M. Abu-Elmagd

28 Isolated Small Bowel Transplantation and Combined Liver-Small Bowel Transplantation, 254
Douglas G. Farmer

29 Living Donor Intestinal Transplantation, 262
Enrico Benedetti, Fabrizio Panaro and Giuliano Testa

30 Isolated Liver Transplantation for Intestinal Failure-Associated Liver Disease, 270
Jean F. Botha and Alan N. Langnas

31 Preservation of the Intestine, 275
Vincent B. Nieuwenhuijs, Mihai Oltean, Henri G. Leuvenink and Rutger J. Ploeg

32 Immediate Postoperative Care of the Intestinal Transplant Recipient, 283
Gabriel J. Hauser, Jeffrey S. Plotkin and Thomas Fishbein

33 Surgical Complications of Intestinal Transplantation, 290
Wendy J. Grant

34 Infections in Small Bowel Transplant Recipients, 297
Alison Freifeld and Andre Kalil

35 Immunosuppression after Intestinal Transplantation, 305
Raquel Garcia-Roca and Rainer Gruessner

36 Immunology of Intestinal Allograft Rejection, 314
Kenneth A. Newell and Jonathan P. Fryer

37 Histopathology of Intestinal Transplantation, 322
Tong Wu and Anthony J. Demetris

38 Long-Term Management of Intestinal Transplant Recipients, 331
Frances R. Malone and Simon P. Horslen

39 Management of Posttransplant Lymphoproliferative Disease, 342
Thomas G. Gross

40 Results of Intestinal Transplantation, 349
David R. Grant and Shimul A. Shah

41 Psychosocial Assessment and Management of the Transplant Patient/Family in Intestinal Transplantation, 357
Jodi Gentleman, Leonard W. Penkoski and James H. Sorrell

42 Financial, Economic and Insurance Issues Pertaining to Intestinal Transplantation: When Is Too Much Not Enough?, 363
Roger W. Evans

Index, 379

Subject Areas: Medicine: general issues [MB]
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