Integrative Mechanobiology
Micro- and Nano- Techniques in Cell Mechanobiology

Experts describe state-of-the-art micro-nano techniques for cell mechanobiology and introduce the most recent advances in the field.

Yu Sun (Edited by), Deok-Ho Kim (Edited by), Craig A. Simmons (Edited by)

9781107078390, Cambridge University Press

Hardback, published 12 November 2015

382 pages, 89 b/w illus.
25.2 x 17.7 x 2 cm, 0.9 kg

The first of its kind, this comprehensive resource integrates cellular mechanobiology with micro-nano techniques to provide unrivalled in-depth coverage of the field, including state-of-the-art methods, recent advances, and biological discoveries. Structured in two parts, the first part offers detailed analysis of innovative micro-nano techniques including FRET imaging, electron cryo-microscopy, micropost arrays, nanotopography devices, laser ablation, and computational image analysis. The second part of the book provides valuable insights into the most recent technological advances and discoveries in areas such as stem cell, heart, bone, brain, tumor, and fibroblast mechanobiology. Written by a team of leading experts and well-recognised researchers, this is an essential resource for students and researchers in biomedical engineering.

Part I. Micro/Nano Techniques in Cell Mechanobiology: 1. Nanotechnologies and FRET imaging in live cells Eddie Y. Chung, Qin Qin, Agamoni Bhattacharyya, Shaoying Lu and Yingxiao Wang
2. Electron microscopy and three-dimensional single-particle analysis as tools for understanding the structural basis of mechanobiology Niels Volkmann and Dorit Hanein
3. Stretchable micropost array cytometry: a powerful tool for cell mechanics and mechanobiology research Yue Shao, Shinuo Weng and Jianping Fu
4. Microscale generation of dynamic forces in cell culture systems Christopher Moraes, Luke A. MacQueen, Yu Sun and Craig A. Simmons
5. Multi-scale topographical approaches for cell mechanobiology studies Koichiro Uto, Elliot Fisher, Hong-Nam Kim, Chang Ho Seo and Deok-Ho Kim
6. Hydrogels with dynamically tunable properties Murat Guvendiren and Jason A. Burdick
7. Micro-engineered tools for studying cell migration in electric fields Jiandong Wu and Francis Lin
8. Laser ablation to investigate cell and tissue mechanics in vivo Teresa Zulueta-Coarasa and Rodrigo Fernandez-Gonzalez
9. Computational image analysis techniques for cell mechanobiology Ge Yang and Hao-Chih Lee
10. Micro- and nanotools to probe cancer cell mechanics and mechanobiology Yasaman Nematbakhsh and Chwee Teck Lim
11. Stimuli-responsive polymeric substrates for cell-matrix mechanobiology Mitsuhiro Ebara and Koichiro Uto
Part II. Recent Progress in Cell Mechanobiology: 12. Forces of nature: understanding the role of mechanotransduction in stem cell differentiation Andrew W. Holle, Jennifer L. Young and Yu Suk Choi
13. Heart valve mechanobiology Craig Simmons
14. Bone cell mechanobiology using micro- and nano-techniques Chao Liu, Kevin Middleton and Lidan You
15. Molecular mechanisms of cellular mechanotransduction in wound healing Vincent F. Fiore, Dwight M. Chambers and Thomas H. Barker
16. Micropost arrays as a means to assess cardiac muscle cells Andrea Leonard, Marita L. Rodriguez and Nathan J. Sniadecki
17. Micro/nanofabrication for the study of biochemical and biomechanical regulation of T cell activation Hye Mi Kim and Junsang Doh
18. Study of tumor angiogenesis using microfluidic approaches Yoojin Shin, Sewoon Han, Hyo-Eun Jeong, Jeong Ah Kim, Jessie S. Jeon and Sid Chung
19. Neuromechanobiology of the brain: mechanics of neuronal structure, function, and pathophysiology Jerel Mueller and William Tyler.

Subject Areas: Mechanics of fluids [TGMF], Cellular biology [cytology PSF], Biophysics [PHVN], Fluid mechanics [PHDF], Biomedical engineering [MQW]