Inhibitors of the Ras Superfamily G-proteins, Part B

This volume of The Enzymes features high-caliber thematic articles on the topic of the inhibitors of the Ras superfamily G-proteins.

Fuyuhiko Tamanoi (Volume editor), Channing J. Der (Volume editor)

9780124201460

Hardback, published 12 December 2013

280 pages
22.9 x 15.1 x 2.2 cm, 0.57 kg

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

1. Discovery of Small-Molecule Ras Inhibitors that Display Anti-Tumor Activity by Interfering with Ras•GTP-Effector Interaction
   Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto and Tohru Kataoka
2. An Orthosteric Inhibitor of the RAS-SOS Interaction
   Seth Nickerson, Stephen T. Joy, Paramjit S. Arora and Dafna Bar-Sagi
3. Conformation-Specific Inhibitors of Raf kinases
   Xiaolun Wang and Kristin Schleicher
4. Inhibitors of the ERK Mitogen-activated Protein Kinase Cascade for Targeting RAS Mutant Cancers
   Leanna Gentry, Ahmed A. Samatar and Channing J. Der
5. Inhibiting the RAS - PI3K Pathway in Cancer Therapy
   Clare Sheridan and Julian Downward
6. The RalGEF/Ral Pathway: Evaluating an Intervention Opportunity for Ras Cancers
   Jonathan M. Cooper, Brian O. Bodemann and Michael A. White
7. p21-Activated Kinase Inhibitors
   Joachim Rudolph, James J. Crawford, Klaus P. Hoeflich, and Jonathan Chernoff
8. Recent Progress in Developing Small Molecule Inhibitors Designed to Interfere with Ras Membrane Association: Towards Inhibiting K-Ras and N-Ras Functions
   Fuyuhiko Tamanoi and Jie Lu
9. Synthetic Lethal Genetic Screens in Ras Mutant Cancers
   Bing Yu and Ji Luo

Subject Areas: Cellular biology [cytology PSF], Molecular biology [PSD]